FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071623902> ?p ?o ?g. }

• W2071623902 endingPage "237" @default.
• W2071623902 startingPage "224" @default.
• W2071623902 abstract "The functions of presenilin 1 (PS1) and how PS1 mutations cause familial Alzheimer's disease (FAD) are incompletely understood. PS1 expression is essential for neurogenesis during embryonic development and may also influence neurogenesis in adult brain. We examined how increasing PS1 expression or expressing an FAD mutant would affect neurogenesis in the adult hippocampus. A neuron-specific enolase (NSE) promoter was used to drive neuronal overexpression of either wild-type human PS1 or the FAD mutant P117L in transgenic mice, and the animals were studied under standard-housing conditions or after environmental enrichment. As judged by bromodeoxyuridine (BrdU) labeling, neural progenitor proliferation rate was mostly unaffected by increasing expression of either wild-type or FAD mutant PS1. However, in both housing conditions, the FAD mutant impaired the survival of BrdU-labeled neural progenitor cells leading to fewer new β-III-tubulin-immunoreactive neurons being generated in FAD mutant animals during the 4-week postlabeling period. The effect was FAD mutant specific in that neural progenitor survival and differentiation in mice overexpressing wild-type human PS1 were similar to nontransgenic controls. Two additional lines of PS1 wild-type and FAD mutant transgenic mice showed similar changes indicating that the effects were not integration site-dependent. These studies demonstrate that a PS1 FAD mutant impairs new neuron production in adult hippocampus by decreasing neural progenitor survival. They also identify a new mechanism whereby PS1 FAD mutants may impair normal neuronal function and may have implications for the physiological functioning of the hippocampus in FAD." @default.
• W2071623902 created "2016-06-24" @default.
• W2071623902 creator A5016775860 @default.
• W2071623902 creator A5020651939 @default.
• W2071623902 creator A5040087226 @default.
• W2071623902 creator A5054795331 @default.
• W2071623902 creator A5056187285 @default.
• W2071623902 creator A5063255808 @default.
• W2071623902 creator A5067834428 @default.
• W2071623902 creator A5068723335 @default.
• W2071623902 creator A5073037534 @default.
• W2071623902 creator A5074710318 @default.
• W2071623902 creator A5088514466 @default.
• W2071623902 creator A5091070290 @default.
• W2071623902 date "2004-08-01" @default.
• W2071623902 modified "2023-10-16" @default.
• W2071623902 title "The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice" @default.
• W2071623902 cites W1481598718 @default.
• W2071623902 cites W1487852103 @default.
• W2071623902 cites W1570630634 @default.
• W2071623902 cites W1591952754 @default.
• W2071623902 cites W1670625131 @default.
• W2071623902 cites W1762207349 @default.
• W2071623902 cites W1763750158 @default.
• W2071623902 cites W1785214340 @default.
• W2071623902 cites W1901042123 @default.
• W2071623902 cites W1919750748 @default.
• W2071623902 cites W1926043920 @default.
• W2071623902 cites W1966227821 @default.
• W2071623902 cites W1968840425 @default.
• W2071623902 cites W1972567838 @default.
• W2071623902 cites W1975627206 @default.
• W2071623902 cites W1976241604 @default.
• W2071623902 cites W1983226940 @default.
• W2071623902 cites W1985784930 @default.
• W2071623902 cites W1995434077 @default.
• W2071623902 cites W1997765501 @default.
• W2071623902 cites W2000706612 @default.
• W2071623902 cites W2005626110 @default.
• W2071623902 cites W2005681172 @default.
• W2071623902 cites W2006257247 @default.
• W2071623902 cites W2010710842 @default.
• W2071623902 cites W2012413593 @default.
• W2071623902 cites W2025828736 @default.
• W2071623902 cites W2025911651 @default.
• W2071623902 cites W2026060908 @default.
• W2071623902 cites W2027731006 @default.
• W2071623902 cites W2028616351 @default.
• W2071623902 cites W2037701234 @default.
• W2071623902 cites W2046209489 @default.
• W2071623902 cites W2048532208 @default.
• W2071623902 cites W2053032855 @default.
• W2071623902 cites W2053116497 @default.
• W2071623902 cites W2064952846 @default.
• W2071623902 cites W2067856703 @default.
• W2071623902 cites W2073005183 @default.
• W2071623902 cites W2076555882 @default.
• W2071623902 cites W2077372110 @default.
• W2071623902 cites W2078946162 @default.
• W2071623902 cites W2079156156 @default.
• W2071623902 cites W2081998222 @default.
• W2071623902 cites W2084761937 @default.
• W2071623902 cites W2092717586 @default.
• W2071623902 cites W2096192426 @default.
• W2071623902 cites W2101077392 @default.
• W2071623902 cites W2101624983 @default.
• W2071623902 cites W2103081123 @default.
• W2071623902 cites W2111121844 @default.
• W2071623902 cites W2111405228 @default.
• W2071623902 cites W2113805610 @default.
• W2071623902 cites W2117789426 @default.
• W2071623902 cites W2119471783 @default.
• W2071623902 cites W2123048941 @default.
• W2071623902 cites W2126974689 @default.
• W2071623902 cites W2132691381 @default.
• W2071623902 cites W2134717514 @default.
• W2071623902 cites W2136487382 @default.
• W2071623902 cites W2136855986 @default.
• W2071623902 cites W2138447190 @default.
• W2071623902 cites W2138886810 @default.
• W2071623902 cites W2139208934 @default.
• W2071623902 cites W2139481908 @default.
• W2071623902 cites W2145235967 @default.
• W2071623902 cites W2150999725 @default.
• W2071623902 cites W2154196079 @default.
• W2071623902 cites W2162026316 @default.
• W2071623902 cites W2163837911 @default.
• W2071623902 cites W2166687069 @default.
• W2071623902 cites W2168010219 @default.
• W2071623902 cites W2168092251 @default.
• W2071623902 cites W2169152986 @default.
• W2071623902 cites W2363633697 @default.
• W2071623902 cites W2394700887 @default.
• W2071623902 cites W4246525350 @default.
• W2071623902 cites W4379089834 @default.
• W2071623902 cites W2182295191 @default.
• W2071623902 doi "https://doi.org/10.1016/j.expneurol.2004.04.002" @default.
• W2071623902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15246822" @default.

• next