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- W2071625493 abstract "6-APA derivatives were considered as selective labels for the construction of bifunctional linkers dedicated to the oriented immobilization of proteins on materials. Sulbactam-like compounds (i.e., 6-β-sulfonamido-penam sulfones) and penicillin G—like compounds (i.e., para-substituted 6-β-phenylacetamido-penams) were prepared and tested as irreversible inhibitors of representative β-lactamases and D,D-peptidases, respectively. The activity of the modified antibiotics was preserved despite their substitution with various anchoring arms. The (2-nitro-4,5-dimethoxy)-benzyl esters revealed of particular interest due to their capacity to acylate BlaR-CTD without deprotection." @default.
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- W2071625493 date "2012-12-01" @default.
- W2071625493 modified "2023-09-23" @default.
- W2071625493 title "6-Aminopenicillanic acid (6-APA) derivatives equipped with anchoring arms" @default.
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- W2071625493 doi "https://doi.org/10.1016/j.tet.2011.10.100" @default.
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