FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071640894> ?p ?o ?g. }

• W2071640894 endingPage "105" @default.
• W2071640894 startingPage "92" @default.
• W2071640894 abstract "Activation of astrocytes surrounding amyloid plaques is a hallmark of Alzheimer disease (AD) with consequences yet poorly understood. Astrocytes are characterized by a high level of intercellular communication mediated by two gap-junction forming proteins, connexin-43 and connexin-30. As astroglial connexins (Cxs) are involved in neuronal dysfunctions and death, we have analyzed their expression pattern in two murine models of AD, that is two different β-amyloid precursor protein (APP)/presenilin1(PS1) mice, using western blot and immunohistochemistry analyzed in confocal microscopy. In young mice at 2 months, before the emergence of β-amyloid (Aβ) deposits, the distribution of both Cxs was similar to that of control mice. In older animals≥4 months, local modifications in connexin immunostaining pattern were observed in the microenvironment of dense core Aβ plaques. In a majority of plaques, an elevated immunoreactivity was detected for both Cxs contributing to the overall increase in connexin expression detected in 18 month old APP/PS1 mice. Activated microglial cells did not contribute to the elevated connexin immunoreactivity that was concentrated in astroglial processes infiltrating the plaques. In a small proportion of plaques (≤15%) a depletion of immunoreactive connexin puncta was also found. As astroglial Cxs participate in neuroglial interactions, their remodeling may contribute to neuronal alterations observed at the periplaque area." @default.
• W2071640894 created "2016-06-24" @default.
• W2071640894 creator A5056041191 @default.
• W2071640894 creator A5061433618 @default.
• W2071640894 creator A5071186353 @default.
• W2071640894 creator A5091312680 @default.
• W2071640894 date "2010-11-01" @default.
• W2071640894 modified "2023-10-02" @default.
• W2071640894 title "Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice" @default.
• W2071640894 cites W1884999644 @default.
• W2071640894 cites W1973361488 @default.
• W2071640894 cites W1974420316 @default.
• W2071640894 cites W1975141413 @default.
• W2071640894 cites W1984899161 @default.
• W2071640894 cites W1989149160 @default.
• W2071640894 cites W1998432972 @default.
• W2071640894 cites W2001334299 @default.
• W2071640894 cites W2001595181 @default.
• W2071640894 cites W2005719973 @default.
• W2071640894 cites W2008831180 @default.
• W2071640894 cites W2011574003 @default.
• W2071640894 cites W2020025443 @default.
• W2071640894 cites W2027616725 @default.
• W2071640894 cites W2036455407 @default.
• W2071640894 cites W2040949523 @default.
• W2071640894 cites W2048371307 @default.
• W2071640894 cites W2048685634 @default.
• W2071640894 cites W2059212904 @default.
• W2071640894 cites W2059463894 @default.
• W2071640894 cites W2065633693 @default.
• W2071640894 cites W2075218913 @default.
• W2071640894 cites W2075252509 @default.
• W2071640894 cites W2078880746 @default.
• W2071640894 cites W2080516466 @default.
• W2071640894 cites W2080558885 @default.
• W2071640894 cites W2083346530 @default.
• W2071640894 cites W2084065789 @default.
• W2071640894 cites W2085123274 @default.
• W2071640894 cites W2087363861 @default.
• W2071640894 cites W2089047096 @default.
• W2071640894 cites W2089380385 @default.
• W2071640894 cites W2089459562 @default.
• W2071640894 cites W2095931805 @default.
• W2071640894 cites W2107015337 @default.
• W2071640894 cites W2118788831 @default.
• W2071640894 cites W2122318491 @default.
• W2071640894 cites W2122828560 @default.
• W2071640894 cites W2123606543 @default.
• W2071640894 cites W2126869810 @default.
• W2071640894 cites W2127338217 @default.
• W2071640894 cites W2127621191 @default.
• W2071640894 cites W2138036162 @default.
• W2071640894 cites W2140162018 @default.
• W2071640894 cites W2144088780 @default.
• W2071640894 cites W2146044361 @default.
• W2071640894 cites W2146073155 @default.
• W2071640894 cites W2146188406 @default.
• W2071640894 cites W2147372806 @default.
• W2071640894 doi "https://doi.org/10.1016/j.neuroscience.2010.08.001" @default.
• W2071640894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20813165" @default.
• W2071640894 hasPublicationYear "2010" @default.
• W2071640894 type Work @default.
• W2071640894 sameAs 2071640894 @default.
• W2071640894 citedByCount "94" @default.
• W2071640894 countsByYear W20716408942012 @default.
• W2071640894 countsByYear W20716408942013 @default.
• W2071640894 countsByYear W20716408942014 @default.
• W2071640894 countsByYear W20716408942015 @default.
• W2071640894 countsByYear W20716408942016 @default.
• W2071640894 countsByYear W20716408942017 @default.
• W2071640894 countsByYear W20716408942018 @default.
• W2071640894 countsByYear W20716408942019 @default.
• W2071640894 countsByYear W20716408942020 @default.
• W2071640894 countsByYear W20716408942021 @default.
• W2071640894 countsByYear W20716408942022 @default.
• W2071640894 countsByYear W20716408942023 @default.
• W2071640894 crossrefType "journal-article" @default.
• W2071640894 hasAuthorship W2071640894A5056041191 @default.
• W2071640894 hasAuthorship W2071640894A5061433618 @default.
• W2071640894 hasAuthorship W2071640894A5071186353 @default.
• W2071640894 hasAuthorship W2071640894A5091312680 @default.
• W2071640894 hasConcept C104317684 @default.
• W2071640894 hasConcept C142724271 @default.
• W2071640894 hasConcept C158157758 @default.
• W2071640894 hasConcept C169760540 @default.
• W2071640894 hasConcept C175344181 @default.
• W2071640894 hasConcept C204232928 @default.
• W2071640894 hasConcept C2776415932 @default.
• W2071640894 hasConcept C2777542381 @default.
• W2071640894 hasConcept C2777633098 @default.
• W2071640894 hasConcept C2779134260 @default.
• W2071640894 hasConcept C2780228694 @default.
• W2071640894 hasConcept C2910362683 @default.
• W2071640894 hasConcept C31705614 @default.
• W2071640894 hasConcept C4224716 @default.
• W2071640894 hasConcept C502032728 @default.
• W2071640894 hasConcept C529278444 @default.
• W2071640894 hasConcept C55493867 @default.

• next