FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071644917> ?p ?o ?g. }

• W2071644917 endingPage "28" @default.
• W2071644917 startingPage "20" @default.
• W2071644917 abstract "Heavy metal tungsten alloys (HMTAs) have been found to be safer alternatives for making military munitions. Recently, some studies demonstrating the toxic potential of HMTAs have raised concern over the safety issues, and further propose that HMTAs exposure may lead to physiological disturbances as well. To look for the systemic effect of acute toxicity of HMTA based metals salt, 1H nuclear magnetic resonance (1H NMR) spectroscopic profiling of rat urine was carried out. Male Sprague Dawley rats were administered (intraperitoneal) low and high dose of mixture of HMTA based metals salt and NMR spectroscopy was carried out in urine samples collected at 8, 24, 72 and 120 h post dosing (p.d.). Serum biochemical parameters and liver histopathology were also conducted. The 1H NMR spectra were analysed using multivariate analysis techniques to show the time- and dose-dependent biochemical variations in post HMTA based metals salt exposure. Urine metabolomic analysis showed changes associated with energy metabolism, amino acids, N-methyl nicotinamide, membrane and gut flora metabolites. Multivariate analysis showed maximum variation with best classification of control and treated groups at 24 h p.d. At the end of the study, for the low dose group most of the changes at metabolite level reverted to control except for the energy metabolites; whereas, in the high dose group some of the changes still persisted. The observations were well correlated with histopathological and serum biochemical parameters. Further, metabolic pathway analysis clarified that amongst all the metabolic pathways analysed, tricarboxylic acid cycle was most affected at all the time points indicating a switchover in energy metabolism from aerobic to anaerobic. These results suggest that exposure of rats to acute doses of HMTA based metals salt disrupts physiological metabolism with moderate injury to the liver, which might indirectly result from heavy metals induced oxidative stress." @default.
• W2071644917 created "2016-06-24" @default.
• W2071644917 creator A5003166009 @default.
• W2071644917 creator A5022449126 @default.
• W2071644917 creator A5023104493 @default.
• W2071644917 creator A5049829674 @default.
• W2071644917 creator A5051194722 @default.
• W2071644917 creator A5059353421 @default.
• W2071644917 creator A5060483993 @default.
• W2071644917 date "2014-03-01" @default.
• W2071644917 modified "2023-09-27" @default.
• W2071644917 title "1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt" @default.
• W2071644917 cites W1498599153 @default.
• W2071644917 cites W183996239 @default.
• W2071644917 cites W190587792 @default.
• W2071644917 cites W1962261520 @default.
• W2071644917 cites W1964452663 @default.
• W2071644917 cites W1968502364 @default.
• W2071644917 cites W1972736261 @default.
• W2071644917 cites W1975580306 @default.
• W2071644917 cites W1976288322 @default.
• W2071644917 cites W1982185581 @default.
• W2071644917 cites W1983673613 @default.
• W2071644917 cites W1985864083 @default.
• W2071644917 cites W1986083508 @default.
• W2071644917 cites W1987193635 @default.
• W2071644917 cites W1990129367 @default.
• W2071644917 cites W1992674175 @default.
• W2071644917 cites W1996437283 @default.
• W2071644917 cites W2007185692 @default.
• W2071644917 cites W2025008809 @default.
• W2071644917 cites W2029484941 @default.
• W2071644917 cites W2035107197 @default.
• W2071644917 cites W2039921669 @default.
• W2071644917 cites W2045748486 @default.
• W2071644917 cites W2061543580 @default.
• W2071644917 cites W2072793952 @default.
• W2071644917 cites W2085523639 @default.
• W2071644917 cites W2090534268 @default.
• W2071644917 cites W2091276319 @default.
• W2071644917 cites W2094547805 @default.
• W2071644917 cites W2096090443 @default.
• W2071644917 cites W2114431588 @default.
• W2071644917 cites W2116058709 @default.
• W2071644917 cites W2119126144 @default.
• W2071644917 cites W2134017403 @default.
• W2071644917 cites W2141610241 @default.
• W2071644917 cites W2162234541 @default.
• W2071644917 cites W2163617578 @default.
• W2071644917 cites W2204311596 @default.
• W2071644917 cites W4294326454 @default.
• W2071644917 doi "https://doi.org/10.1016/j.cbi.2013.12.016" @default.
• W2071644917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24412238" @default.
• W2071644917 hasPublicationYear "2014" @default.
• W2071644917 type Work @default.
• W2071644917 sameAs 2071644917 @default.
• W2071644917 citedByCount "12" @default.
• W2071644917 countsByYear W20716449172014 @default.
• W2071644917 countsByYear W20716449172015 @default.
• W2071644917 countsByYear W20716449172016 @default.
• W2071644917 countsByYear W20716449172017 @default.
• W2071644917 countsByYear W20716449172018 @default.
• W2071644917 countsByYear W20716449172021 @default.
• W2071644917 countsByYear W20716449172022 @default.
• W2071644917 crossrefType "journal-article" @default.
• W2071644917 hasAuthorship W2071644917A5003166009 @default.
• W2071644917 hasAuthorship W2071644917A5022449126 @default.
• W2071644917 hasAuthorship W2071644917A5023104493 @default.
• W2071644917 hasAuthorship W2071644917A5049829674 @default.
• W2071644917 hasAuthorship W2071644917A5051194722 @default.
• W2071644917 hasAuthorship W2071644917A5059353421 @default.
• W2071644917 hasAuthorship W2071644917A5060483993 @default.
• W2071644917 hasConcept C103319777 @default.
• W2071644917 hasConcept C178790620 @default.
• W2071644917 hasConcept C185592680 @default.
• W2071644917 hasConcept C21565614 @default.
• W2071644917 hasConcept C2777477808 @default.
• W2071644917 hasConcept C2780026642 @default.
• W2071644917 hasConcept C29730261 @default.
• W2071644917 hasConcept C43617362 @default.
• W2071644917 hasConcept C55493867 @default.
• W2071644917 hasConcept C62231903 @default.
• W2071644917 hasConcept C66974803 @default.
• W2071644917 hasConcept C71240020 @default.
• W2071644917 hasConcept C71924100 @default.
• W2071644917 hasConcept C98274493 @default.
• W2071644917 hasConceptScore W2071644917C103319777 @default.
• W2071644917 hasConceptScore W2071644917C178790620 @default.
• W2071644917 hasConceptScore W2071644917C185592680 @default.
• W2071644917 hasConceptScore W2071644917C21565614 @default.
• W2071644917 hasConceptScore W2071644917C2777477808 @default.
• W2071644917 hasConceptScore W2071644917C2780026642 @default.
• W2071644917 hasConceptScore W2071644917C29730261 @default.
• W2071644917 hasConceptScore W2071644917C43617362 @default.
• W2071644917 hasConceptScore W2071644917C55493867 @default.
• W2071644917 hasConceptScore W2071644917C62231903 @default.
• W2071644917 hasConceptScore W2071644917C66974803 @default.
• W2071644917 hasConceptScore W2071644917C71240020 @default.

• next