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- W2071658250 abstract "Treatment of acute lymphoblastic leukemia (ALL) has achieved significant progress, however the long-term disease free survival (DFS) of adult ALL patients still does not exceed 20%38% [1-3]. Allogeneic HSCT (allo-HSCT) has been proved to be the most effective treatment for a variety of hematologic malignancies, but the benefits were limited [4]. Although donor lymphocyte infusion (DLI) could restore complete remission (CR) in many patients after transplantation, patients received prophylactic DLI with the risk of fatal graft versus host disease (GVHD). Monitoring minimal residual disease (MRD) allowed for the early detection of trance amount of tumor cells in ALL patients[56]. Whereas, the value of monitoring MRD in relapsed/refractory ALL patients with DLI as intervention after allo-HSCT remains to be evaluated. In this investigation, we reported monitoring MRD in 47 cases of relapsed/refractory ALL after allo-HSCT for 43 months in median and observed that among them 19 patients with a high risk for disease relapse after allo-HSCT were treated with DLI under the guidance of monitoring MRD. Notably, 6 among the 19 cases had no leukemic progression after DLI, suggesting that MRD monitoring has a value in the treatment of relapsed/refractory ALL patients using DLI as intervention after allo-HSCT." @default.
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- W2071658250 date "2009-01-01" @default.
- W2071658250 modified "2023-10-16" @default.
- W2071658250 title "The value of monitoring minimal residual disease in the patients with donor lymphocyte infusion as intervention of relapsed/refractory acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation" @default.
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- W2071658250 doi "https://doi.org/10.1002/ajh.21573" @default.
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