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• W2071660487 abstract "Objective: Bone marrow (BM) dysfunction after trauma and hemorrhagic shock (T/HS) results in a decrease in clonogenic growth of BM progenitors through a plasma-mediated process. Although sex hormones have been shown to modulate some end-organ injury after shock, post-T/HS BM dysfunction has only been studied in male animals. Therefore, the present study examines the effects of sex hormones on post-T/HS BM dysfunction by measuring clonogenic growth of BM progenitors in castrated male rats and in ovariectomized and proestrus female rats. Design: Laboratory experiment. Setting: University surgical research laboratory. Subject: Castrated and noncastrated male and ovariectomized and proestrus female Sprague–Dawley rats. Intervention: All rats were subjected to either T/HS or sham shock with laparotomy (n = 3–5 per group). At 3 hrs after resuscitation, the rats were killed and plasma and BM mononuclear cells from bilateral femurs were harvested. Measurements and Main Results: BM mononuclear cells were cultured for erythroid burst-forming unit and granulocyte-macrophage colony-forming unit colonies to assess the extent of progenitor BM dysfunction. BM from noncastrated male rats subjected to T/HS demonstrated a significant decrease in granulocyte-macrophage colony-forming unit and erythroid burst-forming unit colony formation compared with BM of all the sham-shock groups and with the castrated male and both female rat groups subjected to T/HS. In addition, plasma from noncastrated shocked male rats incubated in vitro with BM cells from unmanipulated male rats caused a significant suppression of BM granulocyte-macrophage colony-forming unit and erythroid burst-forming unit colonies compared with plasma from castrated rats subjected to either sham shock with laparotomy or T/HS. Conclusion: The profound BM dysfunction observed in noncastrated male rats after T/HS is not observed in proestrus female rats and castrated male rats. In addition, the in vitro plasma-mediated BM suppression present in male rats after T/HS is also lost in castrated male rats. Sex hormones seem to play a significant role in BM dysfunction after T/HS." @default.
• W2071660487 created "2016-06-24" @default.
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• W2071660487 date "2007-03-01" @default.
• W2071660487 modified "2023-10-16" @default.
• W2071660487 title "Sex hormones affect bone marrow dysfunction after trauma and hemorrhagic shock" @default.
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• W2071660487 doi "https://doi.org/10.1097/01.ccm.0000256839.50053.1d" @default.
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