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- W2071666063 abstract "Marek's disease (MD) infection has been controlled effectively by vaccination using nononcogenic and/or attenuated oncogenic Marek's disease virus (MDV) vaccines. Thus far, there is little knowledge on the role of cell-mediated immune (CMI) responses during MDV infection or vaccination. To elucidate the importance of MDV proteins in CMI responses, the pp38, Meq, ICP4, or ICP22 genes of an oncogenic strain, GA and the gB, ORF A, A41, or L1 genes of a highly oncogenic strain, RB1B were stably transfected into reticuloendotheliosis virus (REV)-transformed lymphoblastoid cells, CU-91 (MHC:B19B19) and CU-205 (MHC:B21B21). Cell lines positive for MDV gene transcription and/or protein expression were used in a standard 4-hr chromium release assay. Effector cells for this assay were obtained from splenocytes of chickens infected with the oncogenic strain, JM-16/13 or the nononcogenic vaccine strain, SB-1/12. Cell lines expressing MDV pp38, Meq, or gB were lysed by syngeneic but not allogeneic MDV-sensitized splenocytes obtained from chickens ofB19B19andB21B21haplotypes. However, syngeneic CMI responses against ICP4 were detected only inB21B21chickens. CMI responses were not detected againstB19B19andB21B21cell lines expressing A41, L1, ORF A, or ICP22. This report suggests that syngeneic CMI responses against pp38, Meq, ICP4, and gB of GA and RB1B strains, respectively, can be induced in chickens inoculated with JM16/13 or SB-1/12. The difference in CMI response to ICP4 in genetically susceptible (B19B19) and genetically resistant (B21B21) chickens may be an important factor in genetic resistance." @default.
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- W2071666063 date "1996-08-01" @default.
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- W2071666063 title "Syngeneic Marek's Disease Virus (MDV)-Specific Cell-Mediated Immune Responses against Immediate Early, Late, and Unique MDV Proteins" @default.
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- W2071666063 doi "https://doi.org/10.1006/viro.1996.0400" @default.
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