Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071666881> ?p ?o ?g. }
- W2071666881 endingPage "3521" @default.
- W2071666881 startingPage "3509" @default.
- W2071666881 abstract "The cytokine macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity, inflammation and oncogenesis. However, four decades after its identification, the molecular mechanism(s) regulating the expression of the MIF gene remain largely unknown. Analyses of human monocytic (THP-1), epithelial (HeLa and A549) and keratinocytic (HaCat) cells transfected with wild-type, truncated and mutated MIF promoter reporter constructs, and electrophoretic mobility shift assay, chromatin immunoprecipitation, and siRNA inhibition indicated that the transcription factors specificity protein (Sp)1 and cAMP response element-binding protein (CREB) are critical positive regulators of constitutive human MIF gene expression. Albeit located in a cytosine guanine dinucleotide island, the MIF gene was found to be hypomethylated, an observation consistent with high baseline transcriptional activity. Moreover, stimulation of THP-1 cells and of peripheral blood mononuclear cells with microbial products up-regulated phosphorylated Sp1 nuclear content, Sp1 DNA-binding activity, MIF promoter activity and MIF mRNA levels in a MEK1/2-, Sp1-dependent manner. Taken together with previous observations of an important role for MIF in pro-inflammatory macrophage responses, these present findings suggest a key role for Sp1 and CREB in transcriptional regulation of MIF gene expression and MIF-dependent host antimicrobial innate immune defense." @default.
- W2071666881 created "2016-06-24" @default.
- W2071666881 creator A5011794010 @default.
- W2071666881 creator A5013922532 @default.
- W2071666881 creator A5041669530 @default.
- W2071666881 creator A5053283797 @default.
- W2071666881 creator A5065491515 @default.
- W2071666881 date "2007-12-01" @default.
- W2071666881 modified "2023-10-18" @default.
- W2071666881 title "Regulation of constitutive and microbial pathogen-induced humanmacrophage migration inhibitory factor(MIF) gene expression" @default.
- W2071666881 cites W1507700358 @default.
- W2071666881 cites W1510912973 @default.
- W2071666881 cites W1515724419 @default.
- W2071666881 cites W1574734561 @default.
- W2071666881 cites W1621990052 @default.
- W2071666881 cites W1642259399 @default.
- W2071666881 cites W1669881903 @default.
- W2071666881 cites W1906187142 @default.
- W2071666881 cites W1930765292 @default.
- W2071666881 cites W1961498819 @default.
- W2071666881 cites W1964221763 @default.
- W2071666881 cites W1964424946 @default.
- W2071666881 cites W1970452315 @default.
- W2071666881 cites W1980542724 @default.
- W2071666881 cites W1980962483 @default.
- W2071666881 cites W1986837253 @default.
- W2071666881 cites W1988332936 @default.
- W2071666881 cites W1989832114 @default.
- W2071666881 cites W1992286644 @default.
- W2071666881 cites W2001634895 @default.
- W2071666881 cites W2005403372 @default.
- W2071666881 cites W2007784745 @default.
- W2071666881 cites W2009229814 @default.
- W2071666881 cites W2010950394 @default.
- W2071666881 cites W2014778624 @default.
- W2071666881 cites W2015590617 @default.
- W2071666881 cites W2024977803 @default.
- W2071666881 cites W2035352223 @default.
- W2071666881 cites W2036565444 @default.
- W2071666881 cites W2044771066 @default.
- W2071666881 cites W2045123670 @default.
- W2071666881 cites W2046525356 @default.
- W2071666881 cites W2049310294 @default.
- W2071666881 cites W2060591271 @default.
- W2071666881 cites W2062824264 @default.
- W2071666881 cites W2063903921 @default.
- W2071666881 cites W2067458000 @default.
- W2071666881 cites W2072045984 @default.
- W2071666881 cites W2074469807 @default.
- W2071666881 cites W2076111146 @default.
- W2071666881 cites W2078463939 @default.
- W2071666881 cites W2080373340 @default.
- W2071666881 cites W2081743168 @default.
- W2071666881 cites W2087083968 @default.
- W2071666881 cites W2087676487 @default.
- W2071666881 cites W2087968772 @default.
- W2071666881 cites W2088359631 @default.
- W2071666881 cites W2088954042 @default.
- W2071666881 cites W2089926265 @default.
- W2071666881 cites W2090056328 @default.
- W2071666881 cites W2094105923 @default.
- W2071666881 cites W2104686984 @default.
- W2071666881 cites W2106169455 @default.
- W2071666881 cites W2106849532 @default.
- W2071666881 cites W2107529469 @default.
- W2071666881 cites W2110065934 @default.
- W2071666881 cites W2110929110 @default.
- W2071666881 cites W2113198085 @default.
- W2071666881 cites W2129806338 @default.
- W2071666881 cites W2134087142 @default.
- W2071666881 cites W2140261888 @default.
- W2071666881 cites W2141831260 @default.
- W2071666881 cites W2146058212 @default.
- W2071666881 cites W2152058417 @default.
- W2071666881 cites W2163394733 @default.
- W2071666881 cites W4245319638 @default.
- W2071666881 doi "https://doi.org/10.1002/eji.200737357" @default.
- W2071666881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18034423" @default.
- W2071666881 hasPublicationYear "2007" @default.
- W2071666881 type Work @default.
- W2071666881 sameAs 2071666881 @default.
- W2071666881 citedByCount "53" @default.
- W2071666881 countsByYear W20716668812012 @default.
- W2071666881 countsByYear W20716668812013 @default.
- W2071666881 countsByYear W20716668812014 @default.
- W2071666881 countsByYear W20716668812015 @default.
- W2071666881 countsByYear W20716668812016 @default.
- W2071666881 countsByYear W20716668812017 @default.
- W2071666881 countsByYear W20716668812018 @default.
- W2071666881 countsByYear W20716668812019 @default.
- W2071666881 countsByYear W20716668812020 @default.
- W2071666881 countsByYear W20716668812021 @default.
- W2071666881 countsByYear W20716668812022 @default.
- W2071666881 countsByYear W20716668812023 @default.
- W2071666881 crossrefType "journal-article" @default.
- W2071666881 hasAuthorship W2071666881A5011794010 @default.
- W2071666881 hasAuthorship W2071666881A5013922532 @default.
- W2071666881 hasAuthorship W2071666881A5041669530 @default.