Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071680623> ?p ?o ?g. }
- W2071680623 endingPage "66" @default.
- W2071680623 startingPage "55" @default.
- W2071680623 abstract "Problem Macrophages are one of the first immune cells observed at the implantation site. Their presence has been explained as the result of an immune response toward paternal antigens. The mechanisms regulating monocyte migration and differentiation at the implantation site are largely unknown. In the present study, we demonstrate that trophoblast cells regulate monocyte migration and differentiation. We propose that trophoblast cells ‘educate’ monocytes/macrophages to create an adequate environment that promote trophoblast survival. Method of study CD14 + monocytes were isolated from peripheral blood using magnetic beads. Co‐culture experiments were conducted using a two‐chamber system. Monocytes were stimulated with lipopolysaccharide (LPS) and cytokine levels were determined using multiplex cytokine detecting assay. Results Trophoblast cells increase monocyte migration and induce a significant increase in the secretion and production of the pro‐inflammatory cytokines [interleukin‐6 (IL‐6), IL‐8, tumor necrosis factor‐ α ] and chemokines (growth‐related oncogen‐ α , monocyte chemoattractant protein‐1, macrophage inflammatory protein‐1 β , RANTES). Furthermore, the response of monocytes to LPS was different in monocytes pre‐exposed to trophoblast cells. Conclusion The results of this study suggest that trophoblast cells are able to recruit and successfully educate monocytes to produce and secrete a pro‐inflammatory cytokine and chemokine profile supporting its growth and survival. Furthermore we demonstrate that trophoblast cells can modulate monocytes response to bacterial stimuli." @default.
- W2071680623 created "2016-06-24" @default.
- W2071680623 creator A5004608505 @default.
- W2071680623 creator A5005367112 @default.
- W2071680623 creator A5017520053 @default.
- W2071680623 creator A5019925723 @default.
- W2071680623 creator A5062595581 @default.
- W2071680623 creator A5067511554 @default.
- W2071680623 creator A5075812344 @default.
- W2071680623 creator A5078106091 @default.
- W2071680623 creator A5088903979 @default.
- W2071680623 date "2006-11-28" @default.
- W2071680623 modified "2023-10-17" @default.
- W2071680623 title "Trophoblast?Macrophage Interactions: a Regulatory Network for the Protection of Pregnancy" @default.
- W2071680623 cites W1502446969 @default.
- W2071680623 cites W1513189580 @default.
- W2071680623 cites W1525810123 @default.
- W2071680623 cites W1532278869 @default.
- W2071680623 cites W1650254651 @default.
- W2071680623 cites W1973131168 @default.
- W2071680623 cites W1973421833 @default.
- W2071680623 cites W1989542328 @default.
- W2071680623 cites W1989683270 @default.
- W2071680623 cites W2000822846 @default.
- W2071680623 cites W2008245071 @default.
- W2071680623 cites W2010450443 @default.
- W2071680623 cites W2015512471 @default.
- W2071680623 cites W2020151812 @default.
- W2071680623 cites W2020393858 @default.
- W2071680623 cites W2021781735 @default.
- W2071680623 cites W2022235183 @default.
- W2071680623 cites W2030546501 @default.
- W2071680623 cites W2043152809 @default.
- W2071680623 cites W2049701834 @default.
- W2071680623 cites W2063637734 @default.
- W2071680623 cites W2078001921 @default.
- W2071680623 cites W2079284456 @default.
- W2071680623 cites W2092308517 @default.
- W2071680623 cites W2094305843 @default.
- W2071680623 cites W2096346081 @default.
- W2071680623 cites W2111984223 @default.
- W2071680623 cites W2112134219 @default.
- W2071680623 cites W2113646062 @default.
- W2071680623 cites W2125473864 @default.
- W2071680623 cites W2126011537 @default.
- W2071680623 cites W2136098797 @default.
- W2071680623 cites W2156353286 @default.
- W2071680623 cites W4313323932 @default.
- W2071680623 doi "https://doi.org/10.1111/j.1600-0897.2006.00446.x" @default.
- W2071680623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17156192" @default.
- W2071680623 hasPublicationYear "2006" @default.
- W2071680623 type Work @default.
- W2071680623 sameAs 2071680623 @default.
- W2071680623 citedByCount "191" @default.
- W2071680623 countsByYear W20716806232012 @default.
- W2071680623 countsByYear W20716806232013 @default.
- W2071680623 countsByYear W20716806232014 @default.
- W2071680623 countsByYear W20716806232015 @default.
- W2071680623 countsByYear W20716806232016 @default.
- W2071680623 countsByYear W20716806232017 @default.
- W2071680623 countsByYear W20716806232018 @default.
- W2071680623 countsByYear W20716806232019 @default.
- W2071680623 countsByYear W20716806232020 @default.
- W2071680623 countsByYear W20716806232021 @default.
- W2071680623 countsByYear W20716806232022 @default.
- W2071680623 countsByYear W20716806232023 @default.
- W2071680623 crossrefType "journal-article" @default.
- W2071680623 hasAuthorship W2071680623A5004608505 @default.
- W2071680623 hasAuthorship W2071680623A5005367112 @default.
- W2071680623 hasAuthorship W2071680623A5017520053 @default.
- W2071680623 hasAuthorship W2071680623A5019925723 @default.
- W2071680623 hasAuthorship W2071680623A5062595581 @default.
- W2071680623 hasAuthorship W2071680623A5067511554 @default.
- W2071680623 hasAuthorship W2071680623A5075812344 @default.
- W2071680623 hasAuthorship W2071680623A5078106091 @default.
- W2071680623 hasAuthorship W2071680623A5088903979 @default.
- W2071680623 hasConcept C13373296 @default.
- W2071680623 hasConcept C134018914 @default.
- W2071680623 hasConcept C170217031 @default.
- W2071680623 hasConcept C172680121 @default.
- W2071680623 hasConcept C17991360 @default.
- W2071680623 hasConcept C187316574 @default.
- W2071680623 hasConcept C202751555 @default.
- W2071680623 hasConcept C203014093 @default.
- W2071680623 hasConcept C2776953305 @default.
- W2071680623 hasConcept C2777495146 @default.
- W2071680623 hasConcept C2778513237 @default.
- W2071680623 hasConcept C2778690821 @default.
- W2071680623 hasConcept C2778754761 @default.
- W2071680623 hasConcept C2779234561 @default.
- W2071680623 hasConcept C2779244956 @default.
- W2071680623 hasConcept C2781184567 @default.
- W2071680623 hasConcept C49039625 @default.
- W2071680623 hasConcept C54355233 @default.
- W2071680623 hasConcept C55493867 @default.
- W2071680623 hasConcept C86803240 @default.
- W2071680623 hasConcept C8891405 @default.
- W2071680623 hasConcept C95444343 @default.