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- W2071685106 abstract "Tetraspanin CD151 mainly associates with laminin-binding integrins and forms CD151-integrin complex. We previously reported that CD151 could be a potential target for angiogenesis, but the mechanisms involved are still unclear. This study investigated the role of CD151-integrin complex in angiogenesis and the signaling mechanisms involved. Here we showed that CD151 and CD151-AAA mutant were both well expressed at the protein level. CD151 gene transfer promoted angiogenesis and improved skin temperature of the lateral ischemic hindlimb, whereas CD151-AAA mutant abrogated the increase in capillary density and skin temperature. Further, CD151-AAA mutant failed to activate the FAK, ERK, PI3K/Akt/eNOS, and Rac1/Cdc42 signaling pathways. Moreover, CD151-AAA mutant was unavailable to promote bovine aortic endothelial cells (BAECs) proliferation and migration, in contrast to the effects of CD151. The results suggested that formation of CD151-integrin complex was likely to be a prerequisite for CD151-induced angiogenesis and signaling pathways." @default.
- W2071685106 created "2016-06-24" @default.
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- W2071685106 date "2011-04-01" @default.
- W2071685106 modified "2023-09-27" @default.
- W2071685106 title "Role of tetraspanin CD151–α3/α6 integrin complex: Implication in angiogenesisCD151–integrin complex in angiogenesis" @default.
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- W2071685106 doi "https://doi.org/10.1016/j.biocel.2011.01.004" @default.
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