Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071696504> ?p ?o ?g. }
- W2071696504 endingPage "514" @default.
- W2071696504 startingPage "503" @default.
- W2071696504 abstract "In response to injury of the central nervous system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin, and nestin. We have shown that astrocytes in mice deficient for both GFAP and vimentin (GFAP-/-vim-/-) cannot form IFs even when nestin is expressed and are thus devoid of IFs in their reactive state. Here, we have studied the reaction to injury in the central nervous system in GFAP-/-, vimentin-/-, or GFAP-/-vim-/- mice. Glial scar formation appeared normal after spinal cord or brain lesions in GFAP-/- or vimentin-/- mice, but was impaired in GFAP-/-vim-/- mice that developed less dense scars frequently accompanied by bleeding. These results show that GFAP and vimentin are required for proper glial scar formation in the injured central nervous system and that some degree of functional overlap exists between these IF proteins." @default.
- W2071696504 created "2016-06-24" @default.
- W2071696504 creator A5001704767 @default.
- W2071696504 creator A5002895286 @default.
- W2071696504 creator A5023470454 @default.
- W2071696504 creator A5027822011 @default.
- W2071696504 creator A5028865304 @default.
- W2071696504 creator A5042664107 @default.
- W2071696504 creator A5051005847 @default.
- W2071696504 creator A5076436285 @default.
- W2071696504 creator A5077962208 @default.
- W2071696504 creator A5078058223 @default.
- W2071696504 date "1999-05-03" @default.
- W2071696504 modified "2023-10-16" @default.
- W2071696504 title "Abnormal Reaction to Central Nervous System Injury in Mice Lacking Glial Fibrillary Acidic Protein and Vimentin" @default.
- W2071696504 cites W1215934946 @default.
- W2071696504 cites W1551925364 @default.
- W2071696504 cites W1965676841 @default.
- W2071696504 cites W1984610550 @default.
- W2071696504 cites W1985476482 @default.
- W2071696504 cites W1987145582 @default.
- W2071696504 cites W1988866780 @default.
- W2071696504 cites W1993408609 @default.
- W2071696504 cites W2006289803 @default.
- W2071696504 cites W2012893265 @default.
- W2071696504 cites W2019832949 @default.
- W2071696504 cites W2020885687 @default.
- W2071696504 cites W2030770860 @default.
- W2071696504 cites W2035207421 @default.
- W2071696504 cites W2048734728 @default.
- W2071696504 cites W2057147504 @default.
- W2071696504 cites W2059028264 @default.
- W2071696504 cites W2060943628 @default.
- W2071696504 cites W2063208633 @default.
- W2071696504 cites W2078276327 @default.
- W2071696504 cites W2080191288 @default.
- W2071696504 cites W2083092470 @default.
- W2071696504 cites W2099242521 @default.
- W2071696504 cites W2101045265 @default.
- W2071696504 cites W2118379843 @default.
- W2071696504 cites W2118548006 @default.
- W2071696504 cites W2119321274 @default.
- W2071696504 cites W2123748731 @default.
- W2071696504 cites W2126259711 @default.
- W2071696504 cites W2127338217 @default.
- W2071696504 cites W2140732424 @default.
- W2071696504 cites W2148133676 @default.
- W2071696504 cites W2154021054 @default.
- W2071696504 cites W2154104720 @default.
- W2071696504 cites W2157059052 @default.
- W2071696504 cites W2163556487 @default.
- W2071696504 cites W2165582566 @default.
- W2071696504 cites W2412760833 @default.
- W2071696504 cites W2465003802 @default.
- W2071696504 cites W4320800191 @default.
- W2071696504 doi "https://doi.org/10.1083/jcb.145.3.503" @default.
- W2071696504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2185074" @default.
- W2071696504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10225952" @default.
- W2071696504 hasPublicationYear "1999" @default.
- W2071696504 type Work @default.
- W2071696504 sameAs 2071696504 @default.
- W2071696504 citedByCount "373" @default.
- W2071696504 countsByYear W20716965042012 @default.
- W2071696504 countsByYear W20716965042013 @default.
- W2071696504 countsByYear W20716965042014 @default.
- W2071696504 countsByYear W20716965042015 @default.
- W2071696504 countsByYear W20716965042016 @default.
- W2071696504 countsByYear W20716965042017 @default.
- W2071696504 countsByYear W20716965042018 @default.
- W2071696504 countsByYear W20716965042019 @default.
- W2071696504 countsByYear W20716965042020 @default.
- W2071696504 countsByYear W20716965042021 @default.
- W2071696504 countsByYear W20716965042022 @default.
- W2071696504 countsByYear W20716965042023 @default.
- W2071696504 crossrefType "journal-article" @default.
- W2071696504 hasAuthorship W2071696504A5001704767 @default.
- W2071696504 hasAuthorship W2071696504A5002895286 @default.
- W2071696504 hasAuthorship W2071696504A5023470454 @default.
- W2071696504 hasAuthorship W2071696504A5027822011 @default.
- W2071696504 hasAuthorship W2071696504A5028865304 @default.
- W2071696504 hasAuthorship W2071696504A5042664107 @default.
- W2071696504 hasAuthorship W2071696504A5051005847 @default.
- W2071696504 hasAuthorship W2071696504A5076436285 @default.
- W2071696504 hasAuthorship W2071696504A5077962208 @default.
- W2071696504 hasAuthorship W2071696504A5078058223 @default.
- W2071696504 hasBestOaLocation W20716965041 @default.
- W2071696504 hasConcept C136834591 @default.
- W2071696504 hasConcept C142669718 @default.
- W2071696504 hasConcept C142724271 @default.
- W2071696504 hasConcept C147447768 @default.
- W2071696504 hasConcept C1491633281 @default.
- W2071696504 hasConcept C159431405 @default.
- W2071696504 hasConcept C169760540 @default.
- W2071696504 hasConcept C203014093 @default.
- W2071696504 hasConcept C204232928 @default.
- W2071696504 hasConcept C2777542381 @default.
- W2071696504 hasConcept C2777594495 @default.
- W2071696504 hasConcept C2777738006 @default.