FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071698914> ?p ?o ?g. }

• W2071698914 endingPage "349" @default.
• W2071698914 startingPage "339" @default.
• W2071698914 abstract "HLA-DR is a class II major histocompatibility complex antigen which in the periphery confers antigen presenting capability. We have previously shown that this marker is profusely expressed in cortex of elderly and Alzheimer's disease (AD) patients, as is the receptor for the lymphokine interleukin-2. We now report presence of additional immune-related antigens in AD, and distributional differences from normal elderly controls. In gray matter, HLA-DR immunoreactivity is normally sparse, except in AD where it co-localizes with virtually all'neuritic plaques. HLA-DR positive T cells can be demonstrated in Alzheimer's disease brain tissue, as can instances of apposition between putative brain microglia and T cells. In addition, cells with the morphologic characteristics of astrocytes label for natural killer cell antigen (Leu-11), and apparent lymphocytes bearing T helper and T cytotoxic/suppressor cell antigens are observed. These and other data suggest that the glial proliferation and scavenger activity characteristic of Alzheimer's disease may occur in an immune context and may play an important role in the pathogenesis of the disorder." @default.
• W2071698914 created "2016-06-24" @default.
• W2071698914 creator A5033228506 @default.
• W2071698914 creator A5056432690 @default.
• W2071698914 creator A5071704528 @default.
• W2071698914 creator A5087431486 @default.
• W2071698914 date "1988-01-01" @default.
• W2071698914 modified "2023-10-16" @default.
• W2071698914 title "Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease" @default.
• W2071698914 cites W1002797842 @default.
• W2071698914 cites W1490918588 @default.
• W2071698914 cites W1511379621 @default.
• W2071698914 cites W1851819680 @default.
• W2071698914 cites W1961175455 @default.
• W2071698914 cites W1967262708 @default.
• W2071698914 cites W1972941850 @default.
• W2071698914 cites W1972941885 @default.
• W2071698914 cites W1975536870 @default.
• W2071698914 cites W1981021426 @default.
• W2071698914 cites W1985505859 @default.
• W2071698914 cites W1986887709 @default.
• W2071698914 cites W1988945449 @default.
• W2071698914 cites W1990800602 @default.
• W2071698914 cites W2004989086 @default.
• W2071698914 cites W2022009363 @default.
• W2071698914 cites W2026351957 @default.
• W2071698914 cites W2030692398 @default.
• W2071698914 cites W2039904633 @default.
• W2071698914 cites W2043856037 @default.
• W2071698914 cites W2047315565 @default.
• W2071698914 cites W2048483977 @default.
• W2071698914 cites W2049191496 @default.
• W2071698914 cites W2056046302 @default.
• W2071698914 cites W2059174367 @default.
• W2071698914 cites W2059360174 @default.
• W2071698914 cites W2064085880 @default.
• W2071698914 cites W2067709496 @default.
• W2071698914 cites W2073006349 @default.
• W2071698914 cites W2074360298 @default.
• W2071698914 cites W2091159687 @default.
• W2071698914 cites W2091505182 @default.
• W2071698914 cites W2095020892 @default.
• W2071698914 cites W2095310635 @default.
• W2071698914 cites W2124568244 @default.
• W2071698914 cites W2138533094 @default.
• W2071698914 cites W2312933856 @default.
• W2071698914 cites W2410336712 @default.
• W2071698914 doi "https://doi.org/10.1016/s0197-4580(88)80079-4" @default.
• W2071698914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3263583" @default.
• W2071698914 hasPublicationYear "1988" @default.
• W2071698914 type Work @default.
• W2071698914 sameAs 2071698914 @default.
• W2071698914 citedByCount "634" @default.
• W2071698914 countsByYear W20716989142012 @default.
• W2071698914 countsByYear W20716989142013 @default.
• W2071698914 countsByYear W20716989142014 @default.
• W2071698914 countsByYear W20716989142015 @default.
• W2071698914 countsByYear W20716989142016 @default.
• W2071698914 countsByYear W20716989142017 @default.
• W2071698914 countsByYear W20716989142018 @default.
• W2071698914 countsByYear W20716989142019 @default.
• W2071698914 countsByYear W20716989142020 @default.
• W2071698914 countsByYear W20716989142021 @default.
• W2071698914 countsByYear W20716989142022 @default.
• W2071698914 countsByYear W20716989142023 @default.
• W2071698914 crossrefType "journal-article" @default.
• W2071698914 hasAuthorship W2071698914A5033228506 @default.
• W2071698914 hasAuthorship W2071698914A5056432690 @default.
• W2071698914 hasAuthorship W2071698914A5071704528 @default.
• W2071698914 hasAuthorship W2071698914A5087431486 @default.
• W2071698914 hasConcept C142724271 @default.
• W2071698914 hasConcept C147483822 @default.
• W2071698914 hasConcept C154317977 @default.
• W2071698914 hasConcept C188280979 @default.
• W2071698914 hasConcept C202751555 @default.
• W2071698914 hasConcept C203014093 @default.
• W2071698914 hasConcept C207936829 @default.
• W2071698914 hasConcept C2776914184 @default.
• W2071698914 hasConcept C2779134260 @default.
• W2071698914 hasConcept C2779830541 @default.
• W2071698914 hasConcept C2780942790 @default.
• W2071698914 hasConcept C502032728 @default.
• W2071698914 hasConcept C54355233 @default.
• W2071698914 hasConcept C68026918 @default.
• W2071698914 hasConcept C71924100 @default.
• W2071698914 hasConcept C86803240 @default.
• W2071698914 hasConcept C8891405 @default.
• W2071698914 hasConceptScore W2071698914C142724271 @default.
• W2071698914 hasConceptScore W2071698914C147483822 @default.
• W2071698914 hasConceptScore W2071698914C154317977 @default.
• W2071698914 hasConceptScore W2071698914C188280979 @default.
• W2071698914 hasConceptScore W2071698914C202751555 @default.
• W2071698914 hasConceptScore W2071698914C203014093 @default.
• W2071698914 hasConceptScore W2071698914C207936829 @default.
• W2071698914 hasConceptScore W2071698914C2776914184 @default.
• W2071698914 hasConceptScore W2071698914C2779134260 @default.
• W2071698914 hasConceptScore W2071698914C2779830541 @default.
• W2071698914 hasConceptScore W2071698914C2780942790 @default.

• next