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- W2071700013 abstract "The study is of double-blind crossover design. In the first part of the study, rioprostil (300 micrograms and 600 micrograms) is given orally with a solid breakfast to 9 healthy male volunteers. Both doses of rioprostil delay and reduce the 3-h postprandial GIP release. They also reduce the maximal postprandial insulin concentration, but only rioprostil (600 micrograms) reduces the 3-h integrated release of insulin significantly (by approximately 20%). Neither dose modifies the postprandial glucose gastrin levels significantly. In another study two groups of 6 volunteers are studied in parallel; they are given either rioprostil (600 micrograms) or a placebo each evening for 14 days. On the mornings before and on days 13 and 14 of the study the volunteers take a solid breakfast and blood glucose is measured 1 h and 2 h postprandially. The results show that no differences in the basal and postprandial glucose levels are observed. In conclusion, rioprostil given with a meal can reduce the insulin release but it does not change the postprandial blood glucose levels when given as a single dose or repeatedly in an evening dose. This study shows that rioprostil can be given to patients with diabetes." @default.
- W2071700013 created "2016-06-24" @default.
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- W2071700013 date "1989-01-01" @default.
- W2071700013 modified "2023-09-24" @default.
- W2071700013 title "Effects of Rioprostil on the Postprandial Glucose, GIP, Insulin and Gastrin Levels in Volunteers" @default.
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- W2071700013 doi "https://doi.org/10.3109/00365528909091197" @default.
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