Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071705929> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2071705929 endingPage "286" @default.
- W2071705929 startingPage "277" @default.
- W2071705929 abstract "The KV7 (KCNQ) subfamily of voltage-gated K+ channels consists of five members (KV7.1- KV7.5) giving rise to non-inactivating, and slowly activating/deactivating currents mainly expressed in cardiac (KV7.1) and neuronal (KV7.2- KV7.5) tissue. In the present study, using the cut-open oocyte voltage clamp, we studied the relation of the ionic currents from homomeric neuronal Kv7 channels (KV7.2-KV7.5) with the gating currents recorded after K+ conductance blockade from the same channels. Increasing the recording temperature from 18{degree sign}C to 28{degree sign}C accelerated activation/deactivation kinetics of the ionic currents in all homomeric KV7 channels (activation Q10s at 0 mV were 3.8, 4.1, 8.3, and 2.8 for Kv7.2, Kv7.3, Kv7.4 and Kv7.5 channels, respectively), without large changes in currents voltage-dependence; moreover, at 28{degree sign}C, ionic currents carried by KV7.4 channels also showed a significant increase in their maximal value. Gating currents were only resolved in KV7.4 and KV7.5 channels; the size of the ON gating charges at +40 mV was 1.34 ± 0.34 nC for KV7.4, and 0.79 ± 0.20 nC for KV7.5. At 28{degree sign}C, KV7.4 gating currents had the following salient properties: 1) similar time integral of QON and QOFF, indicating no charge immobilization; 2) a left-shift in the V1/2 of the QON/V when compared to the G/V (≈ 50 mV in the presence of 2 mM extracellular Ba2+); 3) a QON decay faster than ionic current activation; and 4) a rising phase in the OFF gating charge after depolarizations larger than 0 mV. These observations suggest that, in KV7.4 channels, VSD movement is followed by a slow and/or low bearing charge step linking to pore opening, a result which may help to clarify the molecular consequence of disease-causing mutations and drugs affecting channel gating." @default.
- W2071705929 created "2016-06-24" @default.
- W2071705929 creator A5021427652 @default.
- W2071705929 creator A5028939983 @default.
- W2071705929 creator A5047764895 @default.
- W2071705929 creator A5057579624 @default.
- W2071705929 date "2009-07-31" @default.
- W2071705929 modified "2023-10-15" @default.
- W2071705929 title "Gating currents from neuronal K<sub>V</sub>7.4 Channels: General features and correlation with the ionic conductance" @default.
- W2071705929 doi "https://doi.org/10.4161/chan.3.4.9477" @default.
- W2071705929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19690464" @default.
- W2071705929 hasPublicationYear "2009" @default.
- W2071705929 type Work @default.
- W2071705929 sameAs 2071705929 @default.
- W2071705929 citedByCount "30" @default.
- W2071705929 countsByYear W20717059292012 @default.
- W2071705929 countsByYear W20717059292013 @default.
- W2071705929 countsByYear W20717059292014 @default.
- W2071705929 countsByYear W20717059292015 @default.
- W2071705929 countsByYear W20717059292016 @default.
- W2071705929 countsByYear W20717059292018 @default.
- W2071705929 countsByYear W20717059292019 @default.
- W2071705929 countsByYear W20717059292021 @default.
- W2071705929 countsByYear W20717059292022 @default.
- W2071705929 countsByYear W20717059292023 @default.
- W2071705929 crossrefType "journal-article" @default.
- W2071705929 hasAuthorship W2071705929A5021427652 @default.
- W2071705929 hasAuthorship W2071705929A5028939983 @default.
- W2071705929 hasAuthorship W2071705929A5047764895 @default.
- W2071705929 hasAuthorship W2071705929A5057579624 @default.
- W2071705929 hasBestOaLocation W20717059291 @default.
- W2071705929 hasConcept C104292427 @default.
- W2071705929 hasConcept C104317684 @default.
- W2071705929 hasConcept C113196181 @default.
- W2071705929 hasConcept C121332964 @default.
- W2071705929 hasConcept C121932024 @default.
- W2071705929 hasConcept C12554922 @default.
- W2071705929 hasConcept C146403970 @default.
- W2071705929 hasConcept C169760540 @default.
- W2071705929 hasConcept C185263204 @default.
- W2071705929 hasConcept C185592680 @default.
- W2071705929 hasConcept C194544171 @default.
- W2071705929 hasConcept C26873012 @default.
- W2071705929 hasConcept C2776104367 @default.
- W2071705929 hasConcept C43617362 @default.
- W2071705929 hasConcept C46141821 @default.
- W2071705929 hasConcept C55493867 @default.
- W2071705929 hasConcept C86803240 @default.
- W2071705929 hasConceptScore W2071705929C104292427 @default.
- W2071705929 hasConceptScore W2071705929C104317684 @default.
- W2071705929 hasConceptScore W2071705929C113196181 @default.
- W2071705929 hasConceptScore W2071705929C121332964 @default.
- W2071705929 hasConceptScore W2071705929C121932024 @default.
- W2071705929 hasConceptScore W2071705929C12554922 @default.
- W2071705929 hasConceptScore W2071705929C146403970 @default.
- W2071705929 hasConceptScore W2071705929C169760540 @default.
- W2071705929 hasConceptScore W2071705929C185263204 @default.
- W2071705929 hasConceptScore W2071705929C185592680 @default.
- W2071705929 hasConceptScore W2071705929C194544171 @default.
- W2071705929 hasConceptScore W2071705929C26873012 @default.
- W2071705929 hasConceptScore W2071705929C2776104367 @default.
- W2071705929 hasConceptScore W2071705929C43617362 @default.
- W2071705929 hasConceptScore W2071705929C46141821 @default.
- W2071705929 hasConceptScore W2071705929C55493867 @default.
- W2071705929 hasConceptScore W2071705929C86803240 @default.
- W2071705929 hasIssue "4" @default.
- W2071705929 hasLocation W20717059291 @default.
- W2071705929 hasOpenAccess W2071705929 @default.
- W2071705929 hasPrimaryLocation W20717059291 @default.
- W2071705929 hasRelatedWork W1636088266 @default.
- W2071705929 hasRelatedWork W1968555577 @default.
- W2071705929 hasRelatedWork W1982014643 @default.
- W2071705929 hasRelatedWork W1982017552 @default.
- W2071705929 hasRelatedWork W1983171985 @default.
- W2071705929 hasRelatedWork W2013035027 @default.
- W2071705929 hasRelatedWork W2015639109 @default.
- W2071705929 hasRelatedWork W2054281527 @default.
- W2071705929 hasRelatedWork W2086964564 @default.
- W2071705929 hasRelatedWork W2100949334 @default.
- W2071705929 hasVolume "3" @default.
- W2071705929 isParatext "false" @default.
- W2071705929 isRetracted "false" @default.
- W2071705929 magId "2071705929" @default.
- W2071705929 workType "article" @default.