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- W2071707443 abstract "The effects of heparin on trypsin have recently been demonstrated to involve inhibition of catalytic activity and degradation of the enzyme by means of an oxidative mechanism. The possibility that α-phenyl N-tert-butylnitrone protects heparin-induced radical formation on trypsin was investigated by measuring amidolytic activity and changes in the structure of trypsin in the presence of heparin with and without α-phenyl N-tert-butylnitrone. The results show that α-phenyl N-tert-butylnitrone does not only prevent, but it even significantly enhances effects of heparin on the enzyme. This is due to the unique property of α-phenyl N-tert-butylnitrone, independently of spin-trapping capacity, to modify the trypsin structure by binding irreversibly to the catalytic triad, at sites distinct from those to which heparin binds." @default.
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- W2071707443 date "1999-06-17" @default.
- W2071707443 modified "2023-09-23" @default.
- W2071707443 title "Spin-trapping agent α-phenyl N -tert-butylnitrone binds to trypsin and enhances heparin-induced inhibition of amidolytic activity and structural degradation of the enzyme" @default.
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- W2071707443 doi "https://doi.org/10.1016/s0014-5793(99)00716-4" @default.
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