Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071707733> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2071707733 abstract "The glucocorticoid receptor (GR) has been reported in neuroendocrine studies to have reduced sensitivity in patients suffering from major depression. GR is transformed to a DNA binding transcriptional activator upon binding of hormone. To become competent of hormone binding, the receptor goes through a cascade of chaperone-assisted folding steps. Heat shock protein 90 (hsp90) appears to be the central platform in this process. Recent genetic studies revealed that one of the chaperone molecules is involved with the treatment response of a subgroup of depressive patients. We embarked in elucidating the role of chaperones in signal transduction of glucocorticoids with the aim to explore potential ways of modulating this pathway via intervention at chaperones. More specifically, we focussed on the function of hsp90, BAG-1, and the large immunophilins FKBP51 and FKBP52 with respect to GR signaling by pharmacological intervention and mutational analysis." @default.
- W2071707733 created "2016-06-24" @default.
- W2071707733 creator A5000212165 @default.
- W2071707733 creator A5013666076 @default.
- W2071707733 creator A5044329719 @default.
- W2071707733 creator A5055586212 @default.
- W2071707733 creator A5068899819 @default.
- W2071707733 date "2004-06-09" @default.
- W2071707733 modified "2023-09-26" @default.
- W2071707733 title "Role of chaperones in signal transduction of the glucocorticoid receptor" @default.
- W2071707733 doi "https://doi.org/10.1055/s-2003-825470" @default.
- W2071707733 hasPublicationYear "2004" @default.
- W2071707733 type Work @default.
- W2071707733 sameAs 2071707733 @default.
- W2071707733 citedByCount "0" @default.
- W2071707733 crossrefType "journal-article" @default.
- W2071707733 hasAuthorship W2071707733A5000212165 @default.
- W2071707733 hasAuthorship W2071707733A5013666076 @default.
- W2071707733 hasAuthorship W2071707733A5044329719 @default.
- W2071707733 hasAuthorship W2071707733A5055586212 @default.
- W2071707733 hasAuthorship W2071707733A5068899819 @default.
- W2071707733 hasConcept C104317684 @default.
- W2071707733 hasConcept C141109615 @default.
- W2071707733 hasConcept C142724271 @default.
- W2071707733 hasConcept C15152581 @default.
- W2071707733 hasConcept C170493617 @default.
- W2071707733 hasConcept C205260736 @default.
- W2071707733 hasConcept C2775932338 @default.
- W2071707733 hasConcept C2775962898 @default.
- W2071707733 hasConcept C54355233 @default.
- W2071707733 hasConcept C55493867 @default.
- W2071707733 hasConcept C59493245 @default.
- W2071707733 hasConcept C62478195 @default.
- W2071707733 hasConcept C71924100 @default.
- W2071707733 hasConcept C86803240 @default.
- W2071707733 hasConcept C88045685 @default.
- W2071707733 hasConcept C95444343 @default.
- W2071707733 hasConceptScore W2071707733C104317684 @default.
- W2071707733 hasConceptScore W2071707733C141109615 @default.
- W2071707733 hasConceptScore W2071707733C142724271 @default.
- W2071707733 hasConceptScore W2071707733C15152581 @default.
- W2071707733 hasConceptScore W2071707733C170493617 @default.
- W2071707733 hasConceptScore W2071707733C205260736 @default.
- W2071707733 hasConceptScore W2071707733C2775932338 @default.
- W2071707733 hasConceptScore W2071707733C2775962898 @default.
- W2071707733 hasConceptScore W2071707733C54355233 @default.
- W2071707733 hasConceptScore W2071707733C55493867 @default.
- W2071707733 hasConceptScore W2071707733C59493245 @default.
- W2071707733 hasConceptScore W2071707733C62478195 @default.
- W2071707733 hasConceptScore W2071707733C71924100 @default.
- W2071707733 hasConceptScore W2071707733C86803240 @default.
- W2071707733 hasConceptScore W2071707733C88045685 @default.
- W2071707733 hasConceptScore W2071707733C95444343 @default.
- W2071707733 hasIssue "05" @default.
- W2071707733 hasLocation W20717077331 @default.
- W2071707733 hasOpenAccess W2071707733 @default.
- W2071707733 hasPrimaryLocation W20717077331 @default.
- W2071707733 hasRelatedWork W1670058493 @default.
- W2071707733 hasRelatedWork W1973539026 @default.
- W2071707733 hasRelatedWork W2033957444 @default.
- W2071707733 hasRelatedWork W2038360974 @default.
- W2071707733 hasRelatedWork W2072832822 @default.
- W2071707733 hasRelatedWork W2076182874 @default.
- W2071707733 hasRelatedWork W2079336387 @default.
- W2071707733 hasRelatedWork W2080839684 @default.
- W2071707733 hasRelatedWork W2962463215 @default.
- W2071707733 hasRelatedWork W4285098517 @default.
- W2071707733 hasVolume "36" @default.
- W2071707733 isParatext "false" @default.
- W2071707733 isRetracted "false" @default.
- W2071707733 magId "2071707733" @default.
- W2071707733 workType "article" @default.