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• W2071708436 abstract "We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype." @default.
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• W2071708436 date "2001-08-01" @default.
• W2071708436 modified "2023-09-27" @default.
• W2071708436 title "Altered dopaminergic transmission in the anorexic anx/anx mouse striatum" @default.
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• W2071708436 doi "https://doi.org/10.1097/00001756-200108280-00029" @default.
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