FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071710913> ?p ?o ?g. }

• W2071710913 endingPage "1180" @default.
• W2071710913 startingPage "1174" @default.
• W2071710913 abstract "Epidemiological studies have shown that exposure to aflatoxin B(1) (AFB(1)) and concurrent infection with hepatitis B lead to a multiplicative risk of developing liver cancer. This chemical-viral interaction can be recapitulated in the tree shrew (Tupia belangeri chinensis). As an initial characterization of this model, the metabolism of AFB(1) in tree shrews has been examined and compared to a sensitive bioassay species, the rat. Utilizing LC/MS/MS, an unreported product, aflatoxin M(1)-N(7)-guanine (AFM(1)-N(7)-guanine), was detected in urine and hepatic DNA samples 24 h after administration of 400 microg/kg AFB(1). In hepatic DNA isolated from tree shrews, AFM(1)-N(7)-guanine was the predominant adduct, 0.74 +/- 0.14 pmol/mg DNA, as compared to 0.37 +/- 0.07 pmol/mg DNA of AFB(1)-N(7)-guanine. Conversely, in rat liver, 6.56 +/- 2.41 pmol/mg DNA of AFB(1)-N(7)-guanine and 0.42 +/- 0.13 pmol/mg DNA of AFM(1)-N(7)-guanine were detected. Rats excreted 1.00 +/- 0.21 pmol AFB(1)-N(7)-guanine/mg creatinine and 0.29 +/- 0.10 pmol AFM(1)-N(7)-guanine/mg creatinine as compared to 0.60 +/- 0.12 pmol AFB(1)-N(7)-guanine/mg creatinine and 0.69 +/- 0.16 pmol AFM(1)-N(7)-guanine/mg creatinine excreted by the tree shrew. Furthermore, tree shrew urine contained 40 times more of the hydroxylated metabolite, AFM(1), than was excreted by rats. In vitro experiments confirmed this difference in oxidative metabolism. Hepatic microsomes isolated from tree shrews failed to produce aflatoxin Q(1) or aflatoxin P(1) but formed a significantly greater amount of AFM(1) than rat microsomes. Bioassays indicated that the tree shrew was considerably more resistant than the rat to AFB(1) hepatocarcinogenesis, which may reflect the significant differences in metabolic profiles of the two species." @default.
• W2071710913 created "2016-06-24" @default.
• W2071710913 creator A5020279845 @default.
• W2071710913 creator A5024908454 @default.
• W2071710913 creator A5064617617 @default.
• W2071710913 creator A5072089972 @default.
• W2071710913 creator A5078418860 @default.
• W2071710913 creator A5084365721 @default.
• W2071710913 creator A5084700499 @default.
• W2071710913 date "2003-08-28" @default.
• W2071710913 modified "2023-10-10" @default.
• W2071710913 title "Identification of Aflatoxin M₁-N⁷-Guanine in Liver and Urine of Tree Shrews and Rats Following Administration of Aflatoxin B₁" @default.
• W2071710913 cites W1595334274 @default.
• W2071710913 cites W1979107338 @default.
• W2071710913 cites W1985170731 @default.
• W2071710913 cites W2045702506 @default.
• W2071710913 cites W2063087703 @default.
• W2071710913 cites W2082914322 @default.
• W2071710913 cites W2090463307 @default.
• W2071710913 cites W2158449128 @default.
• W2071710913 doi "https://doi.org/10.1021/tx034106u" @default.
• W2071710913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12971806" @default.
• W2071710913 hasPublicationYear "2003" @default.
• W2071710913 type Work @default.
• W2071710913 sameAs 2071710913 @default.
• W2071710913 citedByCount "36" @default.
• W2071710913 countsByYear W20717109132012 @default.
• W2071710913 countsByYear W20717109132013 @default.
• W2071710913 countsByYear W20717109132014 @default.
• W2071710913 countsByYear W20717109132015 @default.
• W2071710913 countsByYear W20717109132016 @default.
• W2071710913 countsByYear W20717109132018 @default.
• W2071710913 countsByYear W20717109132019 @default.
• W2071710913 countsByYear W20717109132020 @default.
• W2071710913 countsByYear W20717109132021 @default.
• W2071710913 crossrefType "journal-article" @default.
• W2071710913 hasAuthorship W2071710913A5020279845 @default.
• W2071710913 hasAuthorship W2071710913A5024908454 @default.
• W2071710913 hasAuthorship W2071710913A5064617617 @default.
• W2071710913 hasAuthorship W2071710913A5072089972 @default.
• W2071710913 hasAuthorship W2071710913A5078418860 @default.
• W2071710913 hasAuthorship W2071710913A5084365721 @default.
• W2071710913 hasAuthorship W2071710913A5084700499 @default.
• W2071710913 hasConcept C104317684 @default.
• W2071710913 hasConcept C185592680 @default.
• W2071710913 hasConcept C2777477808 @default.
• W2071710913 hasConcept C2778301229 @default.
• W2071710913 hasConcept C2780026642 @default.
• W2071710913 hasConcept C2780306776 @default.
• W2071710913 hasConcept C31903555 @default.
• W2071710913 hasConcept C40758303 @default.
• W2071710913 hasConcept C512185932 @default.
• W2071710913 hasConcept C552990157 @default.
• W2071710913 hasConcept C55493867 @default.
• W2071710913 hasConcept C86803240 @default.
• W2071710913 hasConceptScore W2071710913C104317684 @default.
• W2071710913 hasConceptScore W2071710913C185592680 @default.
• W2071710913 hasConceptScore W2071710913C2777477808 @default.
• W2071710913 hasConceptScore W2071710913C2778301229 @default.
• W2071710913 hasConceptScore W2071710913C2780026642 @default.
• W2071710913 hasConceptScore W2071710913C2780306776 @default.
• W2071710913 hasConceptScore W2071710913C31903555 @default.
• W2071710913 hasConceptScore W2071710913C40758303 @default.
• W2071710913 hasConceptScore W2071710913C512185932 @default.
• W2071710913 hasConceptScore W2071710913C552990157 @default.
• W2071710913 hasConceptScore W2071710913C55493867 @default.
• W2071710913 hasConceptScore W2071710913C86803240 @default.
• W2071710913 hasIssue "9" @default.
• W2071710913 hasLocation W20717109131 @default.
• W2071710913 hasLocation W20717109132 @default.
• W2071710913 hasOpenAccess W2071710913 @default.
• W2071710913 hasPrimaryLocation W20717109131 @default.
• W2071710913 hasRelatedWork W1989933737 @default.
• W2071710913 hasRelatedWork W1992719829 @default.
• W2071710913 hasRelatedWork W2005397290 @default.
• W2071710913 hasRelatedWork W2059177774 @default.
• W2071710913 hasRelatedWork W2064752311 @default.
• W2071710913 hasRelatedWork W2066945995 @default.
• W2071710913 hasRelatedWork W2068030888 @default.
• W2071710913 hasRelatedWork W2133125857 @default.
• W2071710913 hasRelatedWork W4229373538 @default.
• W2071710913 hasRelatedWork W2496626485 @default.
• W2071710913 hasVolume "16" @default.
• W2071710913 isParatext "false" @default.
• W2071710913 isRetracted "false" @default.
• W2071710913 magId "2071710913" @default.
• W2071710913 workType "article" @default.