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• W2071712061 endingPage "285102" @default.
• W2071712061 startingPage "285102" @default.
• W2071712061 abstract "The advancement in nanotechnology has produced technological and conceptual breakthroughs but the effects nanomaterials have on organisms at the cellular level are poorly understood. Here we report that carboxyl-terminated multi-walled carbon nanotubes (MWCNTs) act as antagonists of three types of potassium channels as assessed by whole-cell patch clamp electrophysiology on undifferentiated pheochromocytoma (PC12) cells. Our results showed that carboxyl-terminated MWCNTs suppress the current densities of Ito, IK and IK1 in a time-dependent and irreversible manner. The suppressions were most distinct 24 h after incubation with MWCNTs. However, MWCNTs did not significantly change the expression levels of reactive oxygen species (ROS) or intracellular free calcium and also did not alter the mitochondrial membrane potential (ΔΨm) in PC12 cells. These results suggest that oxidative stress was not involved in the MWCNTs suppression of Ito, IK and IK1 current densities. Nonetheless, the suppression of potassium currents by MWCNTs will impact on electrical signaling of excitable cells such as neurons and muscles." @default.
• W2071712061 created "2016-06-24" @default.
• W2071712061 creator A5005555777 @default.
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• W2071712061 date "2009-06-23" @default.
• W2071712061 modified "2023-09-30" @default.
• W2071712061 title "Multi-walled carbon nanotubes suppress potassium channel activities in PC12 cells" @default.
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• W2071712061 doi "https://doi.org/10.1088/0957-4484/20/28/285102" @default.
• W2071712061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19546493" @default.
• W2071712061 hasPublicationYear "2009" @default.
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