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• W2071714724 abstract "A peptide nucleic acid (PNA) targeting a splice junction of the murine PTEN primary transcript was covalently conjugated to various basic peptides. When systemically administered to healthy mice, the conjugates displayed sequence-specific alteration of PTEN mRNA splicing as well as inhibition of full length PTEN protein expression. Correlating activity with drug concentration in various tissues indicated strong tissue-dependence, with highest levels of activity observed in adipose tissue. While the presence of a peptide carrier was found to be crucial for efficient delivery to tissue, little difference was observed between the various peptides evaluated. A second PNA-conjugate targeting the murine insulin receptor primary transcript showed a similar activity profile, suggesting that short basic peptides can generally be used to effectively deliver peptide nucleic acids to adipose tissue." @default.
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• W2071714724 date "2010-05-27" @default.
• W2071714724 modified "2023-09-25" @default.
• W2071714724 title "Peptide Nucleic Acids Conjugated to Short Basic Peptides Show Improved Pharmacokinetics and Antisense Activity in Adipose Tissue" @default.
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• W2071714724 doi "https://doi.org/10.1021/jm901489k" @default.
• W2071714724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3072269" @default.
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