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- W2071717872 abstract "Heart failure represents the one major form of heart disease that continues to increase in prevalence, both in the United States and worldwide. There are presently estimated to be 4.9 million patients in the United States with heart failure, with 550,000 new cases per year, representing the primary diagnosis for approximately 999,000 hospital discharges in year 2000. Over the past decade, significant gains have been made in drug therapy for heart failure, with angiotensin converting enzyme (ACE) inhibitors and betablockers providing significant reduction in morbidity and mortality. Nevertheless, over 250,000 annual deaths are at least partly attributable to heart failure. For patients with advanced heart failure, life expectancy and health-related quality of life (H-QOL) may be identifiably limited, despite optimal medical therapy. Until recently, the only additional available treatment for these patients was cardiac transplantation, a procedure performed approximately 2,155 times in the United States in 2002, with donor availability being the limiting factor. In recent years, there have been major advances in device technology and its clinical impact in patients with advanced heart failure. Major categories of devices that are either available or are under development include 1) devices that assume some or all of the work of the heart (ventricular assist device—VAD); 2) devices that electrically resynchronize ventricular contraction (biventricular pacing); 3) devices that reverse life-threatening ventricular arrhythmias (implantable cardiac defibrillator—ICD); 4) devices that unload the heart; 5) devices that impede adverse cardiac remodeling; and 6) devices that monitor cardiac function" @default.
- W2071717872 created "2016-06-24" @default.
- W2071717872 creator A5031383756 @default.
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- W2071717872 date "2004-04-01" @default.
- W2071717872 modified "2023-10-18" @default.
- W2071717872 title "Key issues in trial design for ventricular assist devices: a position statement of the heart failure society of America" @default.
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- W2071717872 doi "https://doi.org/10.1016/j.cardfail.2004.02.009" @default.
- W2071717872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15101019" @default.
- W2071717872 hasPublicationYear "2004" @default.
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