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• W2071718058 abstract "Renal recirculation experiments have been conducted to determine the circulatory behavior of autologous kidneys immediately following removal from the body as well as after 24 hour periods of preservation by means of hypothermia (4° C.) alone and hypothermia (4° C.) combined with oxygen under increased pressure (3 atmospheres absolute). These findings are compared to similar observations on kidneys remaining at room temperature for identical periods of time (essentially dead kidneys). Data have been presented to indicate that the phenomenon of outflow block consistently observed in kidneys recirculated immediately following removal was usually transient and was primarily due to vascular spasm. This is contrasted to essentially dead kidneys in which all evidence of autoregulation was missing and persistent outflow block was associated with vascular dilatation and increased trapping of blood and fluid within the kidney. The circulatory behavior of kidneys preserved for 24 hours by hypothermia (4° C.) alone and by hypothermia (4° C.) and hyperbaric oxygen was intermediate to the above extremes, with the best performance occurring in the group exposed to oxygen under increased pressure. Both groups of preserved kidneys showed cortical arterial and venous dilatation by injection studies, suggesting that the decrease in blood flow observed during recirculation of these kidneys related more to abnormal vascular dilatation than vascular spasm. Renal recirculation experiments have been conducted to determine the circulatory behavior of autologous kidneys immediately following removal from the body as well as after 24 hour periods of preservation by means of hypothermia (4° C.) alone and hypothermia (4° C.) combined with oxygen under increased pressure (3 atmospheres absolute). These findings are compared to similar observations on kidneys remaining at room temperature for identical periods of time (essentially dead kidneys). Data have been presented to indicate that the phenomenon of outflow block consistently observed in kidneys recirculated immediately following removal was usually transient and was primarily due to vascular spasm. This is contrasted to essentially dead kidneys in which all evidence of autoregulation was missing and persistent outflow block was associated with vascular dilatation and increased trapping of blood and fluid within the kidney. The circulatory behavior of kidneys preserved for 24 hours by hypothermia (4° C.) alone and by hypothermia (4° C.) and hyperbaric oxygen was intermediate to the above extremes, with the best performance occurring in the group exposed to oxygen under increased pressure. Both groups of preserved kidneys showed cortical arterial and venous dilatation by injection studies, suggesting that the decrease in blood flow observed during recirculation of these kidneys related more to abnormal vascular dilatation than vascular spasm." @default.
• W2071718058 created "2016-06-24" @default.
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• W2071718058 date "1965-07-01" @default.
• W2071718058 modified "2023-10-17" @default.
• W2071718058 title "The circulatory behavior of isolated and preserved canine kidneys" @default.
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• W2071718058 doi "https://doi.org/10.1016/s0022-4804(65)80072-5" @default.
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