Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071718508> ?p ?o ?g. }
- W2071718508 endingPage "88" @default.
- W2071718508 startingPage "81" @default.
- W2071718508 abstract "Nitric oxide, generated by the nitric oxide synthase (NOS) enzymes, plays pivotal roles in cardiovascular homeostasis and in the pathogenesis of cardiovascular disease. The NOS cofactor, tetrahydrobiopterin (BH4), is an important regulator of NOS function, since BH4 is required to maintain enzymatic coupling of L-arginine oxidation, to produce NO. Loss or oxidation of BH4 to 7,8-dihydrobiopterin (BH2) is associated with NOS uncoupling, resulting in the production of superoxide rather than NO. In addition to key roles in folate metabolism, dihydrofolate reductase (DHFR) can 'recycle' BH2, and thus regenerate BH4. It is therefore likely that net BH4 cellular bioavailability reflects the balance between de novo BH4 synthesis, loss of BH4 by oxidation to BH2, and the regeneration of BH4 by DHFR. Recent studies have implicated BH4 recycling in the direct regulation of eNOS uncoupling, showing that inhibition of BH4 recycling using DHFR-specific siRNA and methotrexate treatment leads to eNOS uncoupling in endothelial cells and the hph-1 mouse model of BH4 deficiency, even in the absence of oxidative stress. These studies indicate that not only BH4 level, but the recycling pathways regulating BH4 bioavailability represent potential therapeutic targets and will be discussed in this review." @default.
- W2071718508 created "2016-06-24" @default.
- W2071718508 creator A5000195279 @default.
- W2071718508 creator A5061543063 @default.
- W2071718508 date "2011-08-01" @default.
- W2071718508 modified "2023-10-16" @default.
- W2071718508 title "Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease" @default.
- W2071718508 cites W133994298 @default.
- W2071718508 cites W1479676079 @default.
- W2071718508 cites W1495441076 @default.
- W2071718508 cites W1503770775 @default.
- W2071718508 cites W1504005082 @default.
- W2071718508 cites W1517621505 @default.
- W2071718508 cites W1530835851 @default.
- W2071718508 cites W1533126574 @default.
- W2071718508 cites W1595822167 @default.
- W2071718508 cites W1800678382 @default.
- W2071718508 cites W1821186896 @default.
- W2071718508 cites W1966397511 @default.
- W2071718508 cites W1967966166 @default.
- W2071718508 cites W1969435323 @default.
- W2071718508 cites W1969649775 @default.
- W2071718508 cites W1970904231 @default.
- W2071718508 cites W1972467026 @default.
- W2071718508 cites W1981905227 @default.
- W2071718508 cites W1982522634 @default.
- W2071718508 cites W1982584549 @default.
- W2071718508 cites W1987672331 @default.
- W2071718508 cites W1988145081 @default.
- W2071718508 cites W1993658191 @default.
- W2071718508 cites W1994365742 @default.
- W2071718508 cites W1995572986 @default.
- W2071718508 cites W2004398529 @default.
- W2071718508 cites W2005744476 @default.
- W2071718508 cites W2009300287 @default.
- W2071718508 cites W2010402015 @default.
- W2071718508 cites W2011089437 @default.
- W2071718508 cites W2014844679 @default.
- W2071718508 cites W2016833774 @default.
- W2071718508 cites W2024848503 @default.
- W2071718508 cites W2026425756 @default.
- W2071718508 cites W2027245158 @default.
- W2071718508 cites W2028671428 @default.
- W2071718508 cites W2029137272 @default.
- W2071718508 cites W2030345435 @default.
- W2071718508 cites W2030562891 @default.
- W2071718508 cites W2030975108 @default.
- W2071718508 cites W2036463932 @default.
- W2071718508 cites W2037000455 @default.
- W2071718508 cites W2037187656 @default.
- W2071718508 cites W2038054788 @default.
- W2071718508 cites W2044610799 @default.
- W2071718508 cites W2044941841 @default.
- W2071718508 cites W2045639174 @default.
- W2071718508 cites W2045799225 @default.
- W2071718508 cites W2050324725 @default.
- W2071718508 cites W2051459142 @default.
- W2071718508 cites W2055706334 @default.
- W2071718508 cites W2056947345 @default.
- W2071718508 cites W205703808 @default.
- W2071718508 cites W2058599067 @default.
- W2071718508 cites W2059353739 @default.
- W2071718508 cites W2061015326 @default.
- W2071718508 cites W2063907656 @default.
- W2071718508 cites W2068249262 @default.
- W2071718508 cites W2068695727 @default.
- W2071718508 cites W2068777040 @default.
- W2071718508 cites W2069153850 @default.
- W2071718508 cites W2076466162 @default.
- W2071718508 cites W2077560102 @default.
- W2071718508 cites W2078515628 @default.
- W2071718508 cites W2080666943 @default.
- W2071718508 cites W2092939065 @default.
- W2071718508 cites W20938829 @default.
- W2071718508 cites W2106121696 @default.
- W2071718508 cites W2106894101 @default.
- W2071718508 cites W2107707818 @default.
- W2071718508 cites W2111579090 @default.
- W2071718508 cites W2119223703 @default.
- W2071718508 cites W2121452230 @default.
- W2071718508 cites W2121815457 @default.
- W2071718508 cites W2125202803 @default.
- W2071718508 cites W2126588700 @default.
- W2071718508 cites W2128888081 @default.
- W2071718508 cites W2129674912 @default.
- W2071718508 cites W2130401548 @default.
- W2071718508 cites W2141112342 @default.
- W2071718508 cites W2143404494 @default.
- W2071718508 cites W2148390554 @default.
- W2071718508 cites W2157403778 @default.
- W2071718508 cites W2158667023 @default.
- W2071718508 cites W2161638887 @default.
- W2071718508 cites W2161701821 @default.
- W2071718508 cites W2164765386 @default.
- W2071718508 cites W2165073849 @default.
- W2071718508 cites W2166737442 @default.
- W2071718508 cites W2169782569 @default.
- W2071718508 cites W2172004618 @default.