FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071719050> ?p ?o ?g. }

• W2071719050 endingPage "143" @default.
• W2071719050 startingPage "137" @default.
• W2071719050 abstract "To determine feasibility and efficacy of concurrent paclitaxel and cisplatin with definitive hyperfractionated radiotherapy (HFRT) in locally advanced head-and-neck squamous cell carcinoma (HNSCC).Forty-two patients stages III to IV head-and-neck squamous cell carcinoma were enrolled in 2 consecutive prospective trials from August 1998 to January 2006. In study 1, 16 patients received HFRT in 2 courses of 39.6 Gy each with a split of 2 weeks with concurrent paclitaxel (175 mg/m) and cisplatin (100 mg/m) on days 1, 21, 36, and 57. In study 2, 26 patients received a continuous course of 74.4 Gy of HFRT with concurrent weekly paclitaxel (50 mg/m) and cisplatin (30 mg/m).Tumor locations included oropharynx 48%, hypopharynx 24%, larynx 12%, paranasal sinuses 7%, salivary gland 2%, oral cavity 2% and unknown primary 5%. In study 1, all patients received 3 to 4 cycles of chemotherapy and completed the programmed radiotherapy course. In study 2, 69% received 5 to 6 cycles of chemotherapy and 92% completed the irradiation. Overall, 93% of objective responses were observed (complete 76%, partial 17%). Median follow-up was 50 months (range: 12-97). Pattern of recurrence was local 8%, distant 13%, and combined 3%. Acute toxicity grades 3 to 4 in studies 1 and 2 was 75% and 88%, respectively (P = ns). Globally, 5-year overall survival were 68%, with a median of 71 months (range: 50-91). On multivariate analysis, male gender (P = 0.04) and complete response (P = 0.01) were predictive of improved survival.HFRT combined with cisplatin and paclitaxel is very active but at the expense of severe toxicity. Efficacy and toxicity in studies.1 and 2 were not different despite completely different treatment strategies (chemotherapy dose intensity vs. radiotherapy dose intensity)." @default.
• W2071719050 created "2016-06-24" @default.
• W2071719050 creator A5006983815 @default.
• W2071719050 creator A5020099657 @default.
• W2071719050 creator A5022287984 @default.
• W2071719050 creator A5022331582 @default.
• W2071719050 creator A5026764232 @default.
• W2071719050 creator A5034706960 @default.
• W2071719050 creator A5040905146 @default.
• W2071719050 creator A5046728389 @default.
• W2071719050 date "2010-04-01" @default.
• W2071719050 modified "2023-10-18" @default.
• W2071719050 title "Concomitant Cisplatin, Paclitaxel, and Hyperfractionated Radiotherapy in Locally Advanced Head and Neck Cancer" @default.
• W2071719050 cites W1993384565 @default.
• W2071719050 cites W1996768837 @default.
• W2071719050 cites W2033572589 @default.
• W2071719050 cites W2047893132 @default.
• W2071719050 cites W2075946022 @default.
• W2071719050 cites W2078397149 @default.
• W2071719050 cites W2083034075 @default.
• W2071719050 cites W2131438781 @default.
• W2071719050 cites W2132513531 @default.
• W2071719050 cites W2133555954 @default.
• W2071719050 cites W2139554459 @default.
• W2071719050 cites W2145703501 @default.
• W2071719050 cites W2146148650 @default.
• W2071719050 cites W2151415400 @default.
• W2071719050 cites W2155019837 @default.
• W2071719050 cites W2167805334 @default.
• W2071719050 cites W2169301532 @default.
• W2071719050 cites W2169981637 @default.
• W2071719050 cites W2331395194 @default.
• W2071719050 cites W4234710258 @default.
• W2071719050 cites W4238732848 @default.
• W2071719050 cites W4293241248 @default.
• W2071719050 doi "https://doi.org/10.1097/coc.0b013e31819d369d" @default.
• W2071719050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19786847" @default.
• W2071719050 hasPublicationYear "2010" @default.
• W2071719050 type Work @default.
• W2071719050 sameAs 2071719050 @default.
• W2071719050 citedByCount "10" @default.
• W2071719050 countsByYear W20717190502012 @default.
• W2071719050 countsByYear W20717190502014 @default.
• W2071719050 countsByYear W20717190502016 @default.
• W2071719050 countsByYear W20717190502017 @default.
• W2071719050 countsByYear W20717190502019 @default.
• W2071719050 countsByYear W20717190502020 @default.
• W2071719050 countsByYear W20717190502022 @default.
• W2071719050 crossrefType "journal-article" @default.
• W2071719050 hasAuthorship W2071719050A5006983815 @default.
• W2071719050 hasAuthorship W2071719050A5020099657 @default.
• W2071719050 hasAuthorship W2071719050A5022287984 @default.
• W2071719050 hasAuthorship W2071719050A5022331582 @default.
• W2071719050 hasAuthorship W2071719050A5026764232 @default.
• W2071719050 hasAuthorship W2071719050A5034706960 @default.
• W2071719050 hasAuthorship W2071719050A5040905146 @default.
• W2071719050 hasAuthorship W2071719050A5046728389 @default.
• W2071719050 hasConcept C121608353 @default.
• W2071719050 hasConcept C126322002 @default.
• W2071719050 hasConcept C126894567 @default.
• W2071719050 hasConcept C141071460 @default.
• W2071719050 hasConcept C143998085 @default.
• W2071719050 hasConcept C155806632 @default.
• W2071719050 hasConcept C188816634 @default.
• W2071719050 hasConcept C2776530083 @default.
• W2071719050 hasConcept C2776694085 @default.
• W2071719050 hasConcept C2776833033 @default.
• W2071719050 hasConcept C2777292972 @default.
• W2071719050 hasConcept C2777546739 @default.
• W2071719050 hasConcept C2777955602 @default.
• W2071719050 hasConcept C2778239845 @default.
• W2071719050 hasConcept C2779384505 @default.
• W2071719050 hasConcept C2780474809 @default.
• W2071719050 hasConcept C509974204 @default.
• W2071719050 hasConcept C71924100 @default.
• W2071719050 hasConceptScore W2071719050C121608353 @default.
• W2071719050 hasConceptScore W2071719050C126322002 @default.
• W2071719050 hasConceptScore W2071719050C126894567 @default.
• W2071719050 hasConceptScore W2071719050C141071460 @default.
• W2071719050 hasConceptScore W2071719050C143998085 @default.
• W2071719050 hasConceptScore W2071719050C155806632 @default.
• W2071719050 hasConceptScore W2071719050C188816634 @default.
• W2071719050 hasConceptScore W2071719050C2776530083 @default.
• W2071719050 hasConceptScore W2071719050C2776694085 @default.
• W2071719050 hasConceptScore W2071719050C2776833033 @default.
• W2071719050 hasConceptScore W2071719050C2777292972 @default.
• W2071719050 hasConceptScore W2071719050C2777546739 @default.
• W2071719050 hasConceptScore W2071719050C2777955602 @default.
• W2071719050 hasConceptScore W2071719050C2778239845 @default.
• W2071719050 hasConceptScore W2071719050C2779384505 @default.
• W2071719050 hasConceptScore W2071719050C2780474809 @default.
• W2071719050 hasConceptScore W2071719050C509974204 @default.
• W2071719050 hasConceptScore W2071719050C71924100 @default.
• W2071719050 hasIssue "2" @default.
• W2071719050 hasLocation W20717190501 @default.
• W2071719050 hasLocation W20717190502 @default.
• W2071719050 hasOpenAccess W2071719050 @default.
• W2071719050 hasPrimaryLocation W20717190501 @default.

• next