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W2071723184 abstract "The H63D polymorphism in HFE has frequently been associated with susceptibility to amyotrophic lateral sclerosis (ALS). Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS. Furthermore, novel therapeutic strategies are being developed targeting this process. Evidence for this genetic association is, however, limited to several small studies. For this reason we studied the H63D polymorphism in a large European cohort including 3962 ALS patients and 5072 control subjects from 7 countries. After meta-analysis of previous studies and current findings we conclude that the H63D polymorphism in HFE is not associated with susceptibility to ALS, age at disease onset, or survival." @default.
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W2071723184 date "2013-05-01" @default.
W2071723184 modified "2023-10-18" @default.
W2071723184 title "H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis" @default.
W2071723184 doi "https://doi.org/10.1016/j.neurobiolaging.2012.07.020" @default.
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