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• W2071724232 abstract "We report that the cell surface mucin CD43 acts as an anti-adhesin on T lymphocytes. CD43-deficient murine lymphocytes homed significantly more frequently to secondary lymphoid organs than wild-type cells. Intravital microscopy of peripheral lymph node venules revealed that CD43-deficient lymphocytes were twice as likely to tether, roll, and stick than wild-type cells. This effect was due to CD43 interference with the homing receptor, L-selectin, and was most pronounced in venules with low L-selectin ligand density. In vitro, CD43-deficient cells tethered to L-selectin ligands more efficiently and rolled more slowly than wild-type lymphocytes. Thus, CD43 exerts a negative regulatory effect on T cell trafficking by counterbalancing L-selectin-mediated adhesion." @default.
• W2071724232 created "2016-06-24" @default.
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• W2071724232 date "1998-03-01" @default.
• W2071724232 modified "2023-10-15" @default.
• W2071724232 title "Negative Regulation of T Cell Homing by CD43" @default.
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• W2071724232 doi "https://doi.org/10.1016/s1074-7613(00)80542-7" @default.
• W2071724232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9529154" @default.
• W2071724232 hasPublicationYear "1998" @default.
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