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• W2071726225 endingPage "33366" @default.
• W2071726225 startingPage "33360" @default.
• W2071726225 abstract "The yeast Y′ element is a highly polymorphic repetitive sequence present in the subtelomeric regions of many yeast telomeres. The Y′ element is classed as either Y′-L or Y′-S, depending on its length. It has been reported that survivors arising from telomerase-deficient yeast mutants compensate for telomere loss by the amplification of Y′ elements. The totalSaccharomyces cerevisiae genome DNA data base was searched for Y′ elements, and 11 Y′-Ls and eight Y′-Ss were identified. As reported previously, many of the sequences were found to contain long open reading frames which potentially encode helicase. We examined the expression of the Y′ elements in telomerase-deficient Δtlc1survivors, in which the TLC1 gene encoding the yeast telomerase template RNA had been disrupted, and found that the Y′ element is highly expressed in the survivors, but not in the wild-type cells. Moreover, we demonstrated that the survivors produce a Y′-encoded protein designated as Y′-Help1 (Y′-helicase protein 1), and that this protein possesses helicase activity. Therefore, we suggest that the Y′ element has a novel and potentially important role in trans, in addition to the well characterized role in cis, in telomerase-independent telomere maintenance in yeast." @default.
• W2071726225 created "2016-06-24" @default.
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• W2071726225 date "1998-12-01" @default.
• W2071726225 modified "2023-10-01" @default.
• W2071726225 title "Y′-Help1, a DNA Helicase Encoded by the Yeast Subtelomeric Y′ Element, Is Induced in Survivors Defective for Telomerase" @default.
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• W2071726225 doi "https://doi.org/10.1074/jbc.273.50.33360" @default.
• W2071726225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9837911" @default.
• W2071726225 hasPublicationYear "1998" @default.
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