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• W2071728067 abstract "Stress-related psychopathology is particularly prevalent in women, although the neurobiological reason(s) for this are unclear. Dopamine (DA) and serotonin (5-HT) systems however, are known to play important adaptive roles in stress and emotion regulation. The aims of the present study included examination of sex differences in stress-related behaviour and neuroendocrine function as well as post mortem neurochemistry, with the main hypothesis that corticolimbic DA and 5-HT systems would show greater functional activity in males than females. Long–Evans rats of both sexes were employed. Additional factors incorporated included differential postnatal experience (handled vs. nonhandled) and adult mild stress experience (acute vs. repeated (5) restraint). Regional neurochemistry measures were conducted separately for left and right hemispheres. Behaviourally, females showed more exploratory behaviour than males in the elevated plus maze and an openfield/holeboard apparatus. Females also exhibited significantly higher levels of adrenocorticotrophic hormone and corticosterone at all time points in response to restraint stress than males across treatment conditions, although both sexes showed similar habituation in stress-induced ACTH activation with repeated mild stress. Neurochemically, females had significantly higher levels of DA (in ventromedial prefrontal cortex (vmPFC), insular cortex and n. accumbens) and 5-HT (in vmPFC, amygdala, dorsal hippocampus and insula) than males. In contrast, males had higher levels of the DA metabolite DOPAC or DOPAC/DA ratios than females in all five regions and higher levels of the 5-HT metabolite 5-HIAA or 5-HIAA/5-HT ratios in vmPFC, amygdala and insula, suggesting greater neurotransmitter utilization in males. Moreover, handling treatment induced a significant male-specific upregulation of 5-HT metabolism in all regions except n. accumbens. Given the adaptive role of 5-HT and DAergic neurotransmission in stress and emotion regulation, the intrinsic sex differences we report in the functional status of these systems across conditions, may be highly relevant to the differential vulnerability to disorders of stress and emotion regulation." @default.
• W2071728067 created "2016-06-24" @default.
• W2071728067 creator A5019846250 @default.
• W2071728067 creator A5064040235 @default.
• W2071728067 creator A5071140709 @default.
• W2071728067 date "2009-03-01" @default.
• W2071728067 modified "2023-10-18" @default.
• W2071728067 title "Sex differences in corticolimbic dopamine and serotonin systems in the rat and the effect of postnatal handling" @default.
• W2071728067 cites W1493305388 @default.
• W2071728067 cites W1504315435 @default.
• W2071728067 cites W151073356 @default.
• W2071728067 cites W1541716248 @default.
• W2071728067 cites W1666074897 @default.
• W2071728067 cites W1783949284 @default.
• W2071728067 cites W1828064201 @default.
• W2071728067 cites W1964375247 @default.
• W2071728067 cites W1966224650 @default.
• W2071728067 cites W1967254881 @default.
• W2071728067 cites W1970374697 @default.
• W2071728067 cites W1972293363 @default.
• W2071728067 cites W1972622243 @default.
• W2071728067 cites W1974792530 @default.
• W2071728067 cites W1979310533 @default.
• W2071728067 cites W1979973497 @default.
• W2071728067 cites W1980920483 @default.
• W2071728067 cites W1981667148 @default.
• W2071728067 cites W1981755144 @default.
• W2071728067 cites W1982925999 @default.
• W2071728067 cites W1983340457 @default.
• W2071728067 cites W1984427714 @default.
• W2071728067 cites W1985543379 @default.
• W2071728067 cites W1990457399 @default.
• W2071728067 cites W1990728215 @default.
• W2071728067 cites W1991948487 @default.
• W2071728067 cites W1991969511 @default.
• W2071728067 cites W1992674129 @default.
• W2071728067 cites W1993410150 @default.
• W2071728067 cites W1993440020 @default.
• W2071728067 cites W1993586827 @default.
• W2071728067 cites W1994716040 @default.
• W2071728067 cites W1998025239 @default.
• W2071728067 cites W1999474741 @default.
• W2071728067 cites W2000567681 @default.
• W2071728067 cites W2000976679 @default.
• W2071728067 cites W2001696943 @default.
• W2071728067 cites W2004026815 @default.
• W2071728067 cites W2006384840 @default.
• W2071728067 cites W2007106611 @default.
• W2071728067 cites W2010792949 @default.
• W2071728067 cites W2011083427 @default.
• W2071728067 cites W2014439045 @default.
• W2071728067 cites W2014570372 @default.
• W2071728067 cites W2015229401 @default.
• W2071728067 cites W2017930909 @default.
• W2071728067 cites W2018826759 @default.
• W2071728067 cites W2019062333 @default.
• W2071728067 cites W2019376105 @default.
• W2071728067 cites W2019978313 @default.
• W2071728067 cites W2020408238 @default.
• W2071728067 cites W2020448764 @default.
• W2071728067 cites W2020903493 @default.
• W2071728067 cites W2024240021 @default.
• W2071728067 cites W2024942225 @default.
• W2071728067 cites W2027548555 @default.
• W2071728067 cites W2028503410 @default.
• W2071728067 cites W2028889226 @default.
• W2071728067 cites W2029881171 @default.
• W2071728067 cites W2031897113 @default.
• W2071728067 cites W2032603793 @default.
• W2071728067 cites W2034093030 @default.
• W2071728067 cites W2035251058 @default.
• W2071728067 cites W2037339106 @default.
• W2071728067 cites W2037749209 @default.
• W2071728067 cites W2038394264 @default.
• W2071728067 cites W2038809119 @default.
• W2071728067 cites W2041121186 @default.
• W2071728067 cites W2041404685 @default.
• W2071728067 cites W2041561931 @default.
• W2071728067 cites W2043541468 @default.
• W2071728067 cites W2044352300 @default.
• W2071728067 cites W2051068515 @default.
• W2071728067 cites W2051126673 @default.
• W2071728067 cites W2052377111 @default.
• W2071728067 cites W2052490837 @default.
• W2071728067 cites W2053956851 @default.
• W2071728067 cites W2054066817 @default.
• W2071728067 cites W2054692302 @default.
• W2071728067 cites W2055299738 @default.
• W2071728067 cites W2060908340 @default.
• W2071728067 cites W2065909153 @default.
• W2071728067 cites W2071887266 @default.
• W2071728067 cites W2073214657 @default.
• W2071728067 cites W2075844054 @default.
• W2071728067 cites W2079099498 @default.
• W2071728067 cites W2084114882 @default.
• W2071728067 cites W2084540782 @default.
• W2071728067 cites W2087002356 @default.
• W2071728067 cites W2087818041 @default.

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