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• W2071728131 abstract "As many structurally diverse chemicals have been reported to function as estrogens, evaluations for estrogenicity of compounds are of widespread concern. Recently, we identified WISP-2 (Wnt-1 inducible signaling pathway protein 2) as a novel estrogen-inducible gene in human breast cancer cells. In this study, we examined whether WISP-2 could be utilized as a marker for screening environmentally relevant compounds for estrogenicity. In MCF-7 cells, progesterone, dexamethasone, tri-iodothyronine, and 2,3,7,8-tetrachlorodibenzo-p-dioxin did not regulate the expression of WISP-2, indicating that its induction is highly specific for hormones that interact with the estrogen receptor. Western blot analysis detected WISP-2 protein induced by 17-beta-estradiol (E2), not only in the cell lysates but also in the culture supernatant of exposed cells, indicating that WISP-2 was a secreted protein. The induction of WISP-2 protein by E2 in the culture supernatant was dose-dependent with estimated EC(50) levels between 10 and 100 pM. Our results demonstrated the capacity to screen environmental compounds for estrogenicity via WISP-2 induction." @default.
• W2071728131 created "2016-06-24" @default.
• W2071728131 creator A5005730268 @default.
• W2071728131 creator A5016654061 @default.
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• W2071728131 date "2002-06-01" @default.
• W2071728131 modified "2023-10-02" @default.
• W2071728131 title "WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells" @default.
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• W2071728131 doi "https://doi.org/10.1016/s0006-291x(02)00530-2" @default.
• W2071728131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12056810" @default.
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