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• W2071728343 abstract "NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycine affinity as well as sensitivity to ifenprodil change significantly with the days in vitro, indicating a reduction of NR2B subunit expression. Pb2+ blocked NMDA current with IC50 approximately 4 microM and this effect decreased significantly during the second week in vitro. In Xenopus laevis oocytes expressing recombinant NR1-NR2A, NR1-NR2B or NR1-NR2C receptors, Pb2+ inhibited glutamate-activated currents with IC50 of 3.3, 2.5 and 4.7 microM respectively. These data indicate that Pb2+ action is dependent on subunit composition and suggest that down-regulation of the NR2B subunit is correlated to a diminished sensitivity to Pb2+ inhibition." @default.
• W2071728343 created "2016-06-24" @default.
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• W2071728343 date "2001-10-01" @default.
• W2071728343 modified "2023-09-23" @default.
• W2071728343 title "Lead inhibition of NMDA channels in native and recombinant receptors" @default.
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• W2071728343 doi "https://doi.org/10.1097/00001756-200110080-00028" @default.
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