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• W2071729239 abstract "Developmental regulation of the mouse Xist gene at the onset of X chromosome inactivation is mediated by RNA stabilization. Here, we show that alternate promoter usage gives rise to distinct stable and unstable RNA isoforms. Unstable Xist transcript initiates at a novel upstream promoter, whereas stable Xist RNA is transcribed from the previously identified promoter and from a novel downstream promoter. Analysis of cells undergoing X inactivation indicates that a developmentally regulated promoter switch mediates stabilization and accumulation of Xist RNA on the inactive X chromosome." @default.
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• W2071729239 date "1998-09-01" @default.
• W2071729239 modified "2023-10-14" @default.
• W2071729239 title "Developmentally Regulated Xist Promoter Switch Mediates Initiation of X Inactivation" @default.
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• W2071729239 doi "https://doi.org/10.1016/s0092-8674(00)81739-0" @default.
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