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- W2071730897 abstract "The technology for knocking out the expression of specific genes in the multiploid protozoan parasite Entamoeba histolytica will be difficult to develop. Our recent successes in inhibiting the expression of a number of genes in E. histolytica by transcription of antisense RNA derives from our previous finding that the promoter of one of the two genes coding for ribosomal protein L21 (EhRPg34) directs the transcription of mRNA that does not bind to polyribosomes 1 Petter R. et al. Gene. 1994; 150: 181-186 Crossref PubMed Scopus (11) Google Scholar , 2 Moshitch-Moshkovitch S. et al. Mol. Microbiol. 1998; 27: 677-685 Crossref PubMed Scopus (15) Google Scholar . Transfectants carrying hybrid plasmids containing genes in the reverse orientation under the control of the EhRPg34 promoter produce a high, stable level of antisense RNA, which causes inhibition of expression of the targeted gene ( 3 Ankri S. et al. Mol. Microbiol. 1998; 28: 777-785 Crossref PubMed Scopus (106) Google Scholar , 4 Ankri S. et al. Mol. Microbiol. 1999; 33: 327-337 Crossref PubMed Scopus (97) Google Scholar , 5 R. Bracha, et al., Mol. Microbiol. ((in press)). Google Scholar ; R. Bracha et al., unpublished). Recently, E. histolytica transfectants containing a plasmid construct 3 Ankri S. et al. Mol. Microbiol. 1998; 28: 777-785 Crossref PubMed Scopus (106) Google Scholar expressing a cysteine protease 5 (CP5) antisense RNA have been independently prepared (T. Zhang et al., unpublished). The CP activity of these transfectants is markedly inhibited (by ∼80%) and the trophozoites cause significantly less damage to the intestinal mucosa and permeability barrier in the severe combined immunodeficient human intestinal xenograft (SCID-HU-INT) mouse model of amebiasis 6 Seydel K.B. et al. Infect. Immun. 1997; 65: 1631-1639 Crossref PubMed Google Scholar ." @default.
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- W2071730897 date "1999-12-01" @default.
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- W2071730897 title "Applying antisense technology to the study of Entamoeba histolytica pathogenesis: Response" @default.
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- W2071730897 doi "https://doi.org/10.1016/s0966-842x(99)01627-3" @default.
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