Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071731471> ?p ?o ?g. }
- W2071731471 abstract "Abstract Both acetylcholine and 8-bromo cyclic GMP depress the contractile response of the isolated frog ventricle. An investigation has been made of the effects of both substances on the metabolism of endogenous 3,5 cyclic nucleotides. The levels of adenosine 3′, 5′ cyclic monophosphate (cyclic AMP) and guanosine 3′, 5′ cyclic monophosphate (cyclic GMP) were measured after superfusing preparations with varying concentrations (10 −10 to 10 −4 m ) of acetylcholine and 8-bromo cyclic GMP. The decline in contractile force was found to be accompanied by a progressive fall in intracellular cyclic AMP and a rise in cyclic GMP levels. Both the decline in contractility and the reduction in endogenous cyclic AMP are attenuated by 10 −4 theophylline. The decline in isometric twitch tension was paralleled, under all conditions, by a quantitatively equivalent reduction in the ratio cyclic AMP: cyclic GMP. The possibility that endogenous cyclic GMP may accelerate the conversion of cyclic AMP to 5 AMP, by stimulating a cyclic GMP-sensitive form of cyclic AMP phosphodiesterase, is discussed." @default.
- W2071731471 created "2016-06-24" @default.
- W2071731471 creator A5044589390 @default.
- W2071731471 creator A5053853216 @default.
- W2071731471 date "1981-11-01" @default.
- W2071731471 modified "2023-09-25" @default.
- W2071731471 title "Evidence that cyclic GMP may regulate cyclic AMP metabolism in the isolated frog ventricle" @default.
- W2071731471 cites W1484500255 @default.
- W2071731471 cites W1505892934 @default.
- W2071731471 cites W1506043065 @default.
- W2071731471 cites W1511828294 @default.
- W2071731471 cites W1575093118 @default.
- W2071731471 cites W1604744954 @default.
- W2071731471 cites W1937933901 @default.
- W2071731471 cites W1951119526 @default.
- W2071731471 cites W1971006184 @default.
- W2071731471 cites W1992383744 @default.
- W2071731471 cites W2002269429 @default.
- W2071731471 cites W2004900178 @default.
- W2071731471 cites W2007115560 @default.
- W2071731471 cites W2016868257 @default.
- W2071731471 cites W2021386671 @default.
- W2071731471 cites W2028519419 @default.
- W2071731471 cites W2029169169 @default.
- W2071731471 cites W2030872048 @default.
- W2071731471 cites W2036415059 @default.
- W2071731471 cites W2046001703 @default.
- W2071731471 cites W2046740305 @default.
- W2071731471 cites W2056889378 @default.
- W2071731471 cites W2057687231 @default.
- W2071731471 cites W2060926729 @default.
- W2071731471 cites W2077619702 @default.
- W2071731471 cites W2115515854 @default.
- W2071731471 cites W2131003047 @default.
- W2071731471 cites W2138151365 @default.
- W2071731471 cites W2237628756 @default.
- W2071731471 cites W2263428273 @default.
- W2071731471 cites W2399762864 @default.
- W2071731471 cites W2402282245 @default.
- W2071731471 cites W2403277721 @default.
- W2071731471 cites W2409144698 @default.
- W2071731471 cites W2413744003 @default.
- W2071731471 cites W2414534724 @default.
- W2071731471 cites W2414962688 @default.
- W2071731471 cites W2415897208 @default.
- W2071731471 cites W2430720179 @default.
- W2071731471 cites W2432375307 @default.
- W2071731471 cites W2462804343 @default.
- W2071731471 cites W2481062608 @default.
- W2071731471 cites W3021645154 @default.
- W2071731471 cites W560679443 @default.
- W2071731471 doi "https://doi.org/10.1016/0022-2828(81)90472-7" @default.
- W2071731471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6275088" @default.
- W2071731471 hasPublicationYear "1981" @default.
- W2071731471 type Work @default.
- W2071731471 sameAs 2071731471 @default.
- W2071731471 citedByCount "40" @default.
- W2071731471 crossrefType "journal-article" @default.
- W2071731471 hasAuthorship W2071731471A5044589390 @default.
- W2071731471 hasAuthorship W2071731471A5053853216 @default.
- W2071731471 hasConcept C104317684 @default.
- W2071731471 hasConcept C126322002 @default.
- W2071731471 hasConcept C134018914 @default.
- W2071731471 hasConcept C16613235 @default.
- W2071731471 hasConcept C181199279 @default.
- W2071731471 hasConcept C185592680 @default.
- W2071731471 hasConcept C2775910092 @default.
- W2071731471 hasConcept C2776991684 @default.
- W2071731471 hasConcept C2777995097 @default.
- W2071731471 hasConcept C2778095195 @default.
- W2071731471 hasConcept C2778524494 @default.
- W2071731471 hasConcept C3020139451 @default.
- W2071731471 hasConcept C39133596 @default.
- W2071731471 hasConcept C512185932 @default.
- W2071731471 hasConcept C55493867 @default.
- W2071731471 hasConcept C62826618 @default.
- W2071731471 hasConcept C71924100 @default.
- W2071731471 hasConcept C79879829 @default.
- W2071731471 hasConcept C86803240 @default.
- W2071731471 hasConceptScore W2071731471C104317684 @default.
- W2071731471 hasConceptScore W2071731471C126322002 @default.
- W2071731471 hasConceptScore W2071731471C134018914 @default.
- W2071731471 hasConceptScore W2071731471C16613235 @default.
- W2071731471 hasConceptScore W2071731471C181199279 @default.
- W2071731471 hasConceptScore W2071731471C185592680 @default.
- W2071731471 hasConceptScore W2071731471C2775910092 @default.
- W2071731471 hasConceptScore W2071731471C2776991684 @default.
- W2071731471 hasConceptScore W2071731471C2777995097 @default.
- W2071731471 hasConceptScore W2071731471C2778095195 @default.
- W2071731471 hasConceptScore W2071731471C2778524494 @default.
- W2071731471 hasConceptScore W2071731471C3020139451 @default.
- W2071731471 hasConceptScore W2071731471C39133596 @default.
- W2071731471 hasConceptScore W2071731471C512185932 @default.
- W2071731471 hasConceptScore W2071731471C55493867 @default.
- W2071731471 hasConceptScore W2071731471C62826618 @default.
- W2071731471 hasConceptScore W2071731471C71924100 @default.
- W2071731471 hasConceptScore W2071731471C79879829 @default.
- W2071731471 hasConceptScore W2071731471C86803240 @default.
- W2071731471 hasLocation W20717314711 @default.
- W2071731471 hasLocation W20717314712 @default.