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- W2071732759 abstract "Les auteurs décrivent la préparation des 1,2:5,6-dianhydro-d-mannitol et -galactitol. La toxicité, les effets hématologiques et l'action inhibitrice sur la croissance tumorale de ces dianhydrides ont été comparés à ceux du 1,6-diméthanosulphonoxy-1,6-dideoxy-d-mannitol (mannitol myleran) et du 1,6-dibromo-1,6-dideoxy-d-mannitol (DBM). Les résultats obtenus montrent que les effets biologiques des dérivés hexitol peuvent être expliqués par la transformation de ceux-ci, in vivo, en des quantités appréciables de dianhydride. The preparation of 1,2:5,6-dianhydro-d-mannitol and -galactitol is described. A study has been made of the toxic, haematological and tumour growth inhibitory effects of these dianhydrides for comparison with those of 1,6-dimethanesulphonoxy-1,6-dideoxy-d-mannitol (mannitol myleran) and 1,6-dibromo-1,6-dideoxy-d-mannitol (DBM). The results are consistent with the view that the biological effects of the hexitol derivatives are mediated by their conversion into significant amounts of the dianhydrides in vivo. Die Herstellung von 1,2:5,6-Dianhydro-d-Mannitol und -galaktitol wird beschrieben. Die toxischen, hämatologischen und tumorhemmenden Effekte dieser Dianhydride werden bestimmt und mit denen des 1,6-Dimethansulfonsäure-Esters des d-Mannitols (Mannitol-Myleran) und des 1,6-Dibrom-1,6-didesoxy-d-Mannitols verglichen. Die Resultate sprechen dafür, dass die biologischen Wirkungen der Hexit-Derivate durch die in vivo-Umwandlung in die Dianhydride vermittelt werden." @default.
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- W2071732759 date "1968-12-01" @default.
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- W2071732759 title "Toxicity, hæmatological effects and anti-tumour activity of epoxides derived from disubstituted hexitols. Mode of action of mannitol myleran and dibromomannitol" @default.
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- W2071732759 doi "https://doi.org/10.1016/0014-2964(68)90046-7" @default.
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