Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071734053> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2071734053 endingPage "1413" @default.
- W2071734053 startingPage "1407" @default.
- W2071734053 abstract "MICs of clarithromycin and its major human metabolite, 14-hydroxy-clarithromycin, for Haemophilus influenzae in combination were reduced two- to fourfold compared with the MICs of each compound alone. Serum reduced the MICs of the parent compound and metabolite two- to fourfold compared with the MICs in medium without serum. In serum spiked with clinically relevant concentrations of clarithromycin and 14-hydroxy-clarithromycin at a fixed ratio of 4:1, 15 of 16 strains (94%) were inhibited and killed by combinations containing 1.2 and 0.3 micrograms/ml, respectively. In time kill experiments, the combination of parent compound and metabolite at one-fourth and one-half of their individual MICs, respectively, reduced bacterial counts by greater than 5 log CFU. The postantibiotic effect of clarithromycin combined with 14-hydroxy-clarithromycin was twice that of clarithromycin when tested alone. When orally administered to gerbils with H. influenzae otitis media, the 14-hydroxy metabolite was significantly more active than clarithromycin in reducing bacterial counts from the middle ear. The in vivo activity of the two compounds in combination was synergistic or additive, depending on the level of H. influenzae present at the time treatment was initiated. Significant reductions in bacterial counts and increases in cure rates were observed when clarithromycin at 50 or 100 mg/kg of body weight was combined with 14-hydroxy-clarithromycin at 12 mg/kg or higher. Results from in vitro and in vivo combinations suggest that routine susceptibility tests and animal efficacy studies with clarithromycin alone may underestimate its potential efficacy against H. influenzae." @default.
- W2071734053 created "2016-06-24" @default.
- W2071734053 creator A5009049184 @default.
- W2071734053 creator A5026852803 @default.
- W2071734053 creator A5035436227 @default.
- W2071734053 creator A5050377850 @default.
- W2071734053 creator A5051824274 @default.
- W2071734053 creator A5082799023 @default.
- W2071734053 date "1990-07-01" @default.
- W2071734053 modified "2023-09-26" @default.
- W2071734053 title "Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans" @default.
- W2071734053 cites W1564674653 @default.
- W2071734053 cites W1596159114 @default.
- W2071734053 cites W1876129944 @default.
- W2071734053 cites W1972934756 @default.
- W2071734053 cites W2001769115 @default.
- W2071734053 cites W2021963495 @default.
- W2071734053 cites W2030371182 @default.
- W2071734053 cites W2031405781 @default.
- W2071734053 cites W2041234314 @default.
- W2071734053 cites W2076828405 @default.
- W2071734053 cites W2132169990 @default.
- W2071734053 cites W2147147035 @default.
- W2071734053 cites W2315609346 @default.
- W2071734053 doi "https://doi.org/10.1128/aac.34.7.1407" @default.
- W2071734053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/175991" @default.
- W2071734053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2143642" @default.
- W2071734053 hasPublicationYear "1990" @default.
- W2071734053 type Work @default.
- W2071734053 sameAs 2071734053 @default.
- W2071734053 citedByCount "137" @default.
- W2071734053 countsByYear W20717340532012 @default.
- W2071734053 countsByYear W20717340532013 @default.
- W2071734053 countsByYear W20717340532014 @default.
- W2071734053 countsByYear W20717340532015 @default.
- W2071734053 countsByYear W20717340532017 @default.
- W2071734053 countsByYear W20717340532018 @default.
- W2071734053 countsByYear W20717340532019 @default.
- W2071734053 countsByYear W20717340532020 @default.
- W2071734053 countsByYear W20717340532021 @default.
- W2071734053 countsByYear W20717340532022 @default.
- W2071734053 crossrefType "journal-article" @default.
- W2071734053 hasAuthorship W2071734053A5009049184 @default.
- W2071734053 hasAuthorship W2071734053A5026852803 @default.
- W2071734053 hasAuthorship W2071734053A5035436227 @default.
- W2071734053 hasAuthorship W2071734053A5050377850 @default.
- W2071734053 hasAuthorship W2071734053A5051824274 @default.
- W2071734053 hasAuthorship W2071734053A5082799023 @default.
- W2071734053 hasBestOaLocation W20717340531 @default.
- W2071734053 hasConcept C150903083 @default.
- W2071734053 hasConcept C202751555 @default.
- W2071734053 hasConcept C207001950 @default.
- W2071734053 hasConcept C2776925733 @default.
- W2071734053 hasConcept C2776962512 @default.
- W2071734053 hasConcept C2777477808 @default.
- W2071734053 hasConcept C3019249092 @default.
- W2071734053 hasConcept C501593827 @default.
- W2071734053 hasConcept C55493867 @default.
- W2071734053 hasConcept C86803240 @default.
- W2071734053 hasConcept C89423630 @default.
- W2071734053 hasConcept C98274493 @default.
- W2071734053 hasConceptScore W2071734053C150903083 @default.
- W2071734053 hasConceptScore W2071734053C202751555 @default.
- W2071734053 hasConceptScore W2071734053C207001950 @default.
- W2071734053 hasConceptScore W2071734053C2776925733 @default.
- W2071734053 hasConceptScore W2071734053C2776962512 @default.
- W2071734053 hasConceptScore W2071734053C2777477808 @default.
- W2071734053 hasConceptScore W2071734053C3019249092 @default.
- W2071734053 hasConceptScore W2071734053C501593827 @default.
- W2071734053 hasConceptScore W2071734053C55493867 @default.
- W2071734053 hasConceptScore W2071734053C86803240 @default.
- W2071734053 hasConceptScore W2071734053C89423630 @default.
- W2071734053 hasConceptScore W2071734053C98274493 @default.
- W2071734053 hasIssue "7" @default.
- W2071734053 hasLocation W20717340531 @default.
- W2071734053 hasLocation W20717340532 @default.
- W2071734053 hasLocation W20717340533 @default.
- W2071734053 hasOpenAccess W2071734053 @default.
- W2071734053 hasPrimaryLocation W20717340531 @default.
- W2071734053 hasRelatedWork W1804686097 @default.
- W2071734053 hasRelatedWork W1991572933 @default.
- W2071734053 hasRelatedWork W2017678966 @default.
- W2071734053 hasRelatedWork W2059981938 @default.
- W2071734053 hasRelatedWork W2065023395 @default.
- W2071734053 hasRelatedWork W2071734053 @default.
- W2071734053 hasRelatedWork W2085037436 @default.
- W2071734053 hasRelatedWork W2091258463 @default.
- W2071734053 hasRelatedWork W2103280019 @default.
- W2071734053 hasRelatedWork W2114205969 @default.
- W2071734053 hasVolume "34" @default.
- W2071734053 isParatext "false" @default.
- W2071734053 isRetracted "false" @default.
- W2071734053 magId "2071734053" @default.
- W2071734053 workType "article" @default.