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• W2071736830 abstract "Much interest has been expressed in the antidepressant potential of nonpeptide, orally active corticotropin-releasing factor (CRF) receptor antagonists in recent years. Therefore, the present investigation examined the antidepressant-like effects of the novel CRF1 receptor antagonist SSR125543 on the exaggerated swim test immobility in the Flinders Sensitive Line rat, a genetic animal model of depression. Chronic treatment with SSR125543 (3, 10, 20, 30 mg/kg, i.p.) for 14 days significantly increased swimming in the Flinders Sensitive Line rats. The reference serotonin reuptake inhibitor fluoxetine (5 mg/kg, i.p.) and the tricyclic antidepressant desipramine (5 mg/kg, i.p.) also significantly increased swimming, as expected. The higher doses of SSR125543 (20 and 30 mg/kg) also significantly increased the abnormally low level of social interaction behavior in the Flinders Sensitive Line rats. Together, these findings indicate that the CRF1 receptor antagonist SSR125543 has both antidepressant- and anxiolytic-like effects in the Flinders Sensitive Line rats." @default.
• W2071736830 created "2016-06-24" @default.
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• W2071736830 date "2004-08-01" @default.
• W2071736830 modified "2023-10-07" @default.
• W2071736830 title "Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression" @default.
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• W2071736830 doi "https://doi.org/10.1016/j.ejphar.2004.06.035" @default.
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