Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071738330> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2071738330 endingPage "2545" @default.
- W2071738330 startingPage "2541" @default.
- W2071738330 abstract "Eleven clones of dengue virus 2 Mexican strain were selected by the size of their lytic plaques. Nucleotide sequences of the clones producing large plaques (D2ML2, D2ML3 and D2ML4) revealed 11 mutations, 10 of which were silent. The substitution at nucleotide 1168 (G-->C) generates one amino acid difference at residue 390 (Asp-->His) of the envelope protein (E). These clones showed high virulence in suckling mice when inoculated intracerebrally (> or = 70% mortality). However, the clones which showed small lytic plaques (D2MS1, D2MS2 and D2MS4) displayed a substitution from Asp-->Asn at the same position and had attenuated virulence. Based on these data, we suggest that substitution of Asp-->His at residue 390 perhaps affects a functionally important structural element that could be a determinant of dengue neurovirulence. This substitution falls in domain III of the E protein, which plays an important role in viral binding; therefore, we propose that the substitution affects virulence and cellular tropism." @default.
- W2071738330 created "2016-06-24" @default.
- W2071738330 creator A5015535998 @default.
- W2071738330 creator A5077445502 @default.
- W2071738330 date "1996-10-01" @default.
- W2071738330 modified "2023-09-30" @default.
- W2071738330 title "A single nucleotide change in the E protein gene of dengue virus 2 Mexican strain affects neurovirulence in mice" @default.
- W2071738330 cites W1557330854 @default.
- W2071738330 cites W158830970 @default.
- W2071738330 cites W1895716069 @default.
- W2071738330 cites W1931705429 @default.
- W2071738330 cites W1973123733 @default.
- W2071738330 cites W1977873235 @default.
- W2071738330 cites W1996987325 @default.
- W2071738330 cites W2038891761 @default.
- W2071738330 cites W2049805941 @default.
- W2071738330 cites W2053085788 @default.
- W2071738330 cites W2072897393 @default.
- W2071738330 cites W2093028387 @default.
- W2071738330 cites W2109285828 @default.
- W2071738330 cites W2129296891 @default.
- W2071738330 cites W2409839276 @default.
- W2071738330 cites W966480989 @default.
- W2071738330 doi "https://doi.org/10.1099/0022-1317-77-10-2541" @default.
- W2071738330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8887488" @default.
- W2071738330 hasPublicationYear "1996" @default.
- W2071738330 type Work @default.
- W2071738330 sameAs 2071738330 @default.
- W2071738330 citedByCount "88" @default.
- W2071738330 countsByYear W20717383302012 @default.
- W2071738330 countsByYear W20717383302013 @default.
- W2071738330 countsByYear W20717383302014 @default.
- W2071738330 countsByYear W20717383302015 @default.
- W2071738330 countsByYear W20717383302016 @default.
- W2071738330 countsByYear W20717383302017 @default.
- W2071738330 countsByYear W20717383302018 @default.
- W2071738330 countsByYear W20717383302019 @default.
- W2071738330 countsByYear W20717383302021 @default.
- W2071738330 countsByYear W20717383302022 @default.
- W2071738330 countsByYear W20717383302023 @default.
- W2071738330 crossrefType "journal-article" @default.
- W2071738330 hasAuthorship W2071738330A5015535998 @default.
- W2071738330 hasAuthorship W2071738330A5077445502 @default.
- W2071738330 hasBestOaLocation W20717383301 @default.
- W2071738330 hasConcept C104317684 @default.
- W2071738330 hasConcept C105702510 @default.
- W2071738330 hasConcept C159047783 @default.
- W2071738330 hasConcept C182615771 @default.
- W2071738330 hasConcept C2522874641 @default.
- W2071738330 hasConcept C2778022156 @default.
- W2071738330 hasConcept C2779635636 @default.
- W2071738330 hasConcept C33602714 @default.
- W2071738330 hasConcept C35693153 @default.
- W2071738330 hasConcept C512185932 @default.
- W2071738330 hasConcept C515207424 @default.
- W2071738330 hasConcept C533803919 @default.
- W2071738330 hasConcept C54355233 @default.
- W2071738330 hasConcept C60987743 @default.
- W2071738330 hasConcept C86803240 @default.
- W2071738330 hasConceptScore W2071738330C104317684 @default.
- W2071738330 hasConceptScore W2071738330C105702510 @default.
- W2071738330 hasConceptScore W2071738330C159047783 @default.
- W2071738330 hasConceptScore W2071738330C182615771 @default.
- W2071738330 hasConceptScore W2071738330C2522874641 @default.
- W2071738330 hasConceptScore W2071738330C2778022156 @default.
- W2071738330 hasConceptScore W2071738330C2779635636 @default.
- W2071738330 hasConceptScore W2071738330C33602714 @default.
- W2071738330 hasConceptScore W2071738330C35693153 @default.
- W2071738330 hasConceptScore W2071738330C512185932 @default.
- W2071738330 hasConceptScore W2071738330C515207424 @default.
- W2071738330 hasConceptScore W2071738330C533803919 @default.
- W2071738330 hasConceptScore W2071738330C54355233 @default.
- W2071738330 hasConceptScore W2071738330C60987743 @default.
- W2071738330 hasConceptScore W2071738330C86803240 @default.
- W2071738330 hasIssue "10" @default.
- W2071738330 hasLocation W20717383301 @default.
- W2071738330 hasLocation W20717383302 @default.
- W2071738330 hasOpenAccess W2071738330 @default.
- W2071738330 hasPrimaryLocation W20717383301 @default.
- W2071738330 hasRelatedWork W1983019855 @default.
- W2071738330 hasRelatedWork W2042809849 @default.
- W2071738330 hasRelatedWork W2071738330 @default.
- W2071738330 hasRelatedWork W2076100628 @default.
- W2071738330 hasRelatedWork W2108939276 @default.
- W2071738330 hasRelatedWork W2170804051 @default.
- W2071738330 hasRelatedWork W2330047668 @default.
- W2071738330 hasRelatedWork W2361241861 @default.
- W2071738330 hasRelatedWork W2926996005 @default.
- W2071738330 hasRelatedWork W3204874602 @default.
- W2071738330 hasVolume "77" @default.
- W2071738330 isParatext "false" @default.
- W2071738330 isRetracted "false" @default.
- W2071738330 magId "2071738330" @default.
- W2071738330 workType "article" @default.