Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071738387> ?p ?o ?g. }
- W2071738387 endingPage "267" @default.
- W2071738387 startingPage "259" @default.
- W2071738387 abstract "Asthma is a serious health problem worldwide, particularly in industrialized countries. Despite a better understanding of the pathophysiology of asthma, there are still considerable gaps in knowledge as well as a need for classes of drugs. ASHMI™ (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora flavescens Aiton (Ku Shen) and Glycyrrhiza uralensis Fisch. ex DC (Gan Cao). It prevents allergic asthma airway hyper-reactivity in mice and inhibits acetylcholine (ACh) induced airway smooth muscle (ASM) contraction in tracheal rings from allergic asthmatic mice. The purpose of this research was to identify individual herb(s) and their active compound(s) that inhibit ASM contraction. It was found that S. flavescens, but not G. lucidum or G. uralensis aqueous extracts, inhibited ASM contraction in tracheal rings from asthmatic mice. Bioassay-guided isolation and identification of flavonoid fractions/compound(s) via methylene chloride extraction, preparative HPLC fractionation, and LC-MS and NMR spectroscopic analyses showed that trifolirhizin is an active constituent that inhibits acetylcholine mediated ASM contraction or directly relaxes pre-contracted ASM independent of β2-adrenoceptors." @default.
- W2071738387 created "2016-06-24" @default.
- W2071738387 creator A5012873342 @default.
- W2071738387 creator A5012898979 @default.
- W2071738387 creator A5015552885 @default.
- W2071738387 creator A5026369750 @default.
- W2071738387 creator A5036740014 @default.
- W2071738387 creator A5039879148 @default.
- W2071738387 creator A5051829015 @default.
- W2071738387 creator A5058914276 @default.
- W2071738387 creator A5062824684 @default.
- W2071738387 creator A5071319432 @default.
- W2071738387 date "2013-11-01" @default.
- W2071738387 modified "2023-09-26" @default.
- W2071738387 title "The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction" @default.
- W2071738387 cites W1513956942 @default.
- W2071738387 cites W1968391579 @default.
- W2071738387 cites W1978801965 @default.
- W2071738387 cites W1978866162 @default.
- W2071738387 cites W1986772700 @default.
- W2071738387 cites W2003305246 @default.
- W2071738387 cites W2006601417 @default.
- W2071738387 cites W2013361230 @default.
- W2071738387 cites W2017963874 @default.
- W2071738387 cites W2021221840 @default.
- W2071738387 cites W2031513763 @default.
- W2071738387 cites W2034063869 @default.
- W2071738387 cites W2048768148 @default.
- W2071738387 cites W2053786162 @default.
- W2071738387 cites W2053990128 @default.
- W2071738387 cites W2056367946 @default.
- W2071738387 cites W2068835057 @default.
- W2071738387 cites W2072197107 @default.
- W2071738387 cites W2078761628 @default.
- W2071738387 cites W2082466693 @default.
- W2071738387 cites W2082715077 @default.
- W2071738387 cites W2087196444 @default.
- W2071738387 cites W2093697585 @default.
- W2071738387 cites W2100554611 @default.
- W2071738387 cites W2102985419 @default.
- W2071738387 cites W2118090034 @default.
- W2071738387 cites W2120825158 @default.
- W2071738387 cites W2121774438 @default.
- W2071738387 cites W2131719942 @default.
- W2071738387 cites W2133460340 @default.
- W2071738387 cites W2151477207 @default.
- W2071738387 cites W2158853562 @default.
- W2071738387 cites W2169395860 @default.
- W2071738387 cites W2170576139 @default.
- W2071738387 cites W2235543163 @default.
- W2071738387 cites W2397937056 @default.
- W2071738387 cites W2418786105 @default.
- W2071738387 cites W4232246738 @default.
- W2071738387 cites W43489776 @default.
- W2071738387 doi "https://doi.org/10.1016/j.phytochem.2013.07.023" @default.
- W2071738387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4118489" @default.
- W2071738387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23993294" @default.
- W2071738387 hasPublicationYear "2013" @default.
- W2071738387 type Work @default.
- W2071738387 sameAs 2071738387 @default.
- W2071738387 citedByCount "42" @default.
- W2071738387 countsByYear W20717383872013 @default.
- W2071738387 countsByYear W20717383872014 @default.
- W2071738387 countsByYear W20717383872015 @default.
- W2071738387 countsByYear W20717383872016 @default.
- W2071738387 countsByYear W20717383872017 @default.
- W2071738387 countsByYear W20717383872018 @default.
- W2071738387 countsByYear W20717383872019 @default.
- W2071738387 countsByYear W20717383872020 @default.
- W2071738387 countsByYear W20717383872021 @default.
- W2071738387 countsByYear W20717383872022 @default.
- W2071738387 countsByYear W20717383872023 @default.
- W2071738387 crossrefType "journal-article" @default.
- W2071738387 hasAuthorship W2071738387A5012873342 @default.
- W2071738387 hasAuthorship W2071738387A5012898979 @default.
- W2071738387 hasAuthorship W2071738387A5015552885 @default.
- W2071738387 hasAuthorship W2071738387A5026369750 @default.
- W2071738387 hasAuthorship W2071738387A5036740014 @default.
- W2071738387 hasAuthorship W2071738387A5039879148 @default.
- W2071738387 hasAuthorship W2071738387A5051829015 @default.
- W2071738387 hasAuthorship W2071738387A5058914276 @default.
- W2071738387 hasAuthorship W2071738387A5062824684 @default.
- W2071738387 hasAuthorship W2071738387A5071319432 @default.
- W2071738387 hasBestOaLocation W20717383872 @default.
- W2071738387 hasConcept C126322002 @default.
- W2071738387 hasConcept C142724271 @default.
- W2071738387 hasConcept C163415756 @default.
- W2071738387 hasConcept C185592680 @default.
- W2071738387 hasConcept C204787440 @default.
- W2071738387 hasConcept C2775910092 @default.
- W2071738387 hasConcept C2776545273 @default.
- W2071738387 hasConcept C2778004101 @default.
- W2071738387 hasConcept C2778484605 @default.
- W2071738387 hasConcept C2779054382 @default.
- W2071738387 hasConcept C2779626144 @default.
- W2071738387 hasConcept C2779655422 @default.
- W2071738387 hasConcept C2779969877 @default.
- W2071738387 hasConcept C43617362 @default.