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• W2071738609 abstract "Unlike its mammalian hosts, the opportunistic fungal pathogen Pneumocystis carinii harbors group I self‐splicing introns in its chromosomal genes encoding rRNA. This difference between pathogen and host suggests that intron splicing is a promising target for chemotherapy. We have found that intron splicing in vitro is inhibited by the anti‐ Pneumocystis agent pentamidine and by a series of pentamidine analogues, as well as by some aminoglycosides, tetracycline, L‐arginine and ethidium bromide. Further studies will be needed to determine if this is the mechanism of action of pentamidine against P. carinii ." @default.
• W2071738609 created "2016-06-24" @default.
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• W2071738609 date "1994-01-01" @default.
• W2071738609 modified "2023-10-03" @default.
• W2071738609 title "Inhibition of In Vitro Splicing of a Group I Intron of Pneumocystis carinii" @default.
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• W2071738609 doi "https://doi.org/10.1111/j.1550-7408.1994.tb05931.x" @default.
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