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- W2071738705 abstract "Abstract Extracellular Ca ++ , a ubiquitous cation in the soluble environment of cells both free living and within the human body, regulates most aspects of amoeboid cell motility, including shape, uropod formation, pseudopod formation, velocity, and turning in Dictyostelium discoideum . Hence it affects the efficiency of both basic motile behavior and chemotaxis. Extracellular Ca ++ is optimal at 10 mM. A gradient of the chemoattractant cAMP generated in the absence of added Ca ++ only affects turning, but in combination with extracellular Ca ++ , enhances the effects of extracellular Ca ++ . Potassium, at 40 mM, can partially substitute for Ca ++ . Mg ++ , Mn ++ , Zn ++ , and Na + cannot. Extracellular Ca ++ , or K + , also induce the cortical localization of myosin II in a polar fashion. The effects of Ca ++ , K + or a cAMP gradient do not appear to be similarly mediated by an increase in the general pool of free cytosolic Ca ++ . These results suggest a model, in which each agent functioning through different signaling systems, converge to affect the cortical localization of myosin II, which in turn effects the behavioral changes leading to efficient cell motility and chemotaxis. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc." @default.
- W2071738705 created "2016-06-24" @default.
- W2071738705 creator A5003935045 @default.
- W2071738705 creator A5010753904 @default.
- W2071738705 creator A5079572031 @default.
- W2071738705 date "2009-04-10" @default.
- W2071738705 modified "2023-09-25" @default.
- W2071738705 title "The effects of extracellular calcium on motility, pseudopod and uropod formation, chemotaxis, and the cortical localization of myosin II in<i>Dictyostelium discoideum</i>" @default.
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