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• W2071745068 abstract "The presence of the α-globin frameshift mutant, Hb Wayne, in three generations of a second family is described. The data include a hematological evaluation of the four heterozygotes, structural characterization of the variant, the use of HPLC for the separation of tryptic and chymotryptic peptides, functional analyses of the isolated variant showing high affinity for oxygen and the (near) absence of a Bohr effect, and α chain gene organization analyses with restriction endonuclease technology suggesting that the Hb Wayne heterozygote has a full complement of four α globin genes." @default.
• W2071745068 created "2016-06-24" @default.
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• W2071745068 date "1984-01-01" @default.
• W2071745068 modified "2023-09-26" @default.
• W2071745068 title "HB Wayne, the Frameshift Variant with Extended α Chains Observed in a Caucasian Family from Alabama" @default.
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• W2071745068 doi "https://doi.org/10.3109/03630268408996956" @default.
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