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- W2071750706 abstract "A green method for the diastereoselective synthesis of dihydrofuropyrido[2,3-d]pyrimidines via the reaction of 6-amino-1,3-dimethyl pyrimidine-2,4(1H,3H)-dione, aldehydes and 1-(2-oxo-2-phenylethyl)pyridin-1-ium bromides as a pyridinium ylide base on an organocatalyst assisted domino Knoevenagel condensation–Michael addition–cyclization is investigated. To the best our knowledge, employing 6-amino-1,3-dimethyl pyrimidine-2,4(1H,3H)-dione for the synthesis of dihydrofuropyrido[2,3-d]pyrimidines has not been report yet. This synthesis serves as a nice addition to group-assistant-purification (GAP) chemistry in which purification via chromatography and recrystallization can be avoided, and the pure products were obtained simply by washing the crude products with ethanol." @default.
- W2071750706 created "2016-06-24" @default.
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- W2071750706 date "2014-01-01" @default.
- W2071750706 modified "2023-10-16" @default.
- W2071750706 title "Domino Knoevenagel condensation–Michael addition–cyclization for the diastereoselective synthesis of dihydrofuropyrido[2,3-d]pyrimidines via pyridinium ylides in water" @default.
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- W2071750706 doi "https://doi.org/10.1039/c3ra45795h" @default.
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