FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071752662> ?p ?o ?g. }

• W2071752662 endingPage "290" @default.
• W2071752662 startingPage "284" @default.
• W2071752662 abstract "A new toxin acting on K+ channels, maurotoxin (MTX), has been purified to homogeneity from the venom of the chactoid scorpion Scorpio maurus. MTX is a basic single chain 34 amino acid residue polypeptide, amidated at its C terminal, and crosslinked by four disulfide bridges. It shows 29-68% sequence identity with other K+ channel toxins, and presents an original disulfide pattern, the last two half-cystine residues (31-34) being connected. Although the first three disulfide bonds have not been defined experimentally, modelling based on the structure of charybdotoxin favored two combinations out of six, one of which has two bridges (3-24 and 9-29) in common with the general motif of scorpion toxins. The last bridge would connect residues 13 and 19. MTX inhibits the binding to rat brain synaptosomal membranes of both [125I]apamin, a SK(Ca) channel blocker (IC50 5 nM), and [125I]kaliotoxin, a Kv channel blocker (IC50 30 pM). MTX blocks the Kv1.1, Kv1.2 and Kv1.3 currents expressed in Xenopus oocytes with IC50 of 45, 0.8 and 180 nM, respectively. MTX represents a member of a new class of short toxins with 4 disulfide bridges, active on voltage-dependent K+ channel and also competing with apamin for binding to its receptor." @default.
• W2071752662 created "2016-06-24" @default.
• W2071752662 creator A5001024627 @default.
• W2071752662 creator A5008575369 @default.
• W2071752662 creator A5010667769 @default.
• W2071752662 creator A5027997594 @default.
• W2071752662 creator A5039233754 @default.
• W2071752662 creator A5040401471 @default.
• W2071752662 creator A5051611497 @default.
• W2071752662 creator A5055176979 @default.
• W2071752662 creator A5073392669 @default.
• W2071752662 date "1997-04-14" @default.
• W2071752662 modified "2023-10-09" @default.
• W2071752662 title "Maurotoxin, a four disulfide bridge toxin from <i>Scorpio maurus</i> venom: purification, structure and action on potassium channels" @default.
• W2071752662 cites W1512465642 @default.
• W2071752662 cites W1571383380 @default.
• W2071752662 cites W1579386572 @default.
• W2071752662 cites W1609685783 @default.
• W2071752662 cites W1965952074 @default.
• W2071752662 cites W1969239953 @default.
• W2071752662 cites W1975085160 @default.
• W2071752662 cites W1985087276 @default.
• W2071752662 cites W1985095190 @default.
• W2071752662 cites W1990640328 @default.
• W2071752662 cites W1998469634 @default.
• W2071752662 cites W2010574101 @default.
• W2071752662 cites W2036209063 @default.
• W2071752662 cites W2045695538 @default.
• W2071752662 cites W2048754200 @default.
• W2071752662 cites W2050216084 @default.
• W2071752662 cites W2050335943 @default.
• W2071752662 cites W2070015190 @default.
• W2071752662 cites W2091499426 @default.
• W2071752662 cites W2106852901 @default.
• W2071752662 cites W2123148055 @default.
• W2071752662 cites W2137605357 @default.
• W2071752662 cites W2300917456 @default.
• W2071752662 doi "https://doi.org/10.1016/s0014-5793(97)00285-8" @default.
• W2071752662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9136903" @default.
• W2071752662 hasPublicationYear "1997" @default.
• W2071752662 type Work @default.
• W2071752662 sameAs 2071752662 @default.
• W2071752662 citedByCount "97" @default.
• W2071752662 countsByYear W20717526622012 @default.
• W2071752662 countsByYear W20717526622013 @default.
• W2071752662 countsByYear W20717526622014 @default.
• W2071752662 countsByYear W20717526622015 @default.
• W2071752662 countsByYear W20717526622016 @default.
• W2071752662 countsByYear W20717526622017 @default.
• W2071752662 countsByYear W20717526622018 @default.
• W2071752662 countsByYear W20717526622019 @default.
• W2071752662 countsByYear W20717526622020 @default.
• W2071752662 countsByYear W20717526622022 @default.
• W2071752662 countsByYear W20717526622023 @default.
• W2071752662 crossrefType "journal-article" @default.
• W2071752662 hasAuthorship W2071752662A5001024627 @default.
• W2071752662 hasAuthorship W2071752662A5008575369 @default.
• W2071752662 hasAuthorship W2071752662A5010667769 @default.
• W2071752662 hasAuthorship W2071752662A5027997594 @default.
• W2071752662 hasAuthorship W2071752662A5039233754 @default.
• W2071752662 hasAuthorship W2071752662A5040401471 @default.
• W2071752662 hasAuthorship W2071752662A5051611497 @default.
• W2071752662 hasAuthorship W2071752662A5055176979 @default.
• W2071752662 hasAuthorship W2071752662A5073392669 @default.
• W2071752662 hasBestOaLocation W20717526621 @default.
• W2071752662 hasConcept C12554922 @default.
• W2071752662 hasConcept C153461711 @default.
• W2071752662 hasConcept C178790620 @default.
• W2071752662 hasConcept C181911157 @default.
• W2071752662 hasConcept C185592680 @default.
• W2071752662 hasConcept C2776676993 @default.
• W2071752662 hasConcept C2776919887 @default.
• W2071752662 hasConcept C2777884321 @default.
• W2071752662 hasConcept C2778457506 @default.
• W2071752662 hasConcept C2779281246 @default.
• W2071752662 hasConcept C2779448229 @default.
• W2071752662 hasConcept C2780419564 @default.
• W2071752662 hasConcept C519063684 @default.
• W2071752662 hasConcept C55493867 @default.
• W2071752662 hasConcept C71240020 @default.
• W2071752662 hasConcept C83743174 @default.
• W2071752662 hasConcept C86803240 @default.
• W2071752662 hasConceptScore W2071752662C12554922 @default.
• W2071752662 hasConceptScore W2071752662C153461711 @default.
• W2071752662 hasConceptScore W2071752662C178790620 @default.
• W2071752662 hasConceptScore W2071752662C181911157 @default.
• W2071752662 hasConceptScore W2071752662C185592680 @default.
• W2071752662 hasConceptScore W2071752662C2776676993 @default.
• W2071752662 hasConceptScore W2071752662C2776919887 @default.
• W2071752662 hasConceptScore W2071752662C2777884321 @default.
• W2071752662 hasConceptScore W2071752662C2778457506 @default.
• W2071752662 hasConceptScore W2071752662C2779281246 @default.
• W2071752662 hasConceptScore W2071752662C2779448229 @default.
• W2071752662 hasConceptScore W2071752662C2780419564 @default.
• W2071752662 hasConceptScore W2071752662C519063684 @default.
• W2071752662 hasConceptScore W2071752662C55493867 @default.
• W2071752662 hasConceptScore W2071752662C71240020 @default.
• W2071752662 hasConceptScore W2071752662C83743174 @default.

• next