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• W2071752687 abstract "Oral infection with Porphyromonas (P.) gingivalis causes periodontitis that is manifested by the destruction of gingival connective tissues. Although a few types of antibiotics are effective against the infection, its use induces the appearance of drug-resistant bacteria. The present study shows that the fermented product of Aspergillus (A.) oryzae S-03, cultivated on the fat-removed soybean, inhibits the cell growth of the P. gingivalis. Likewise, the fermented product of the S-03 strain cultured for 26∼42 h displays an inhibitory activity to gingipain as a virulence factor of P. gingivalis. The activity is not lost even with heat treatment at 100°C for 15 min. We also demonstrate that the S-03 strain exhibits high protease activity. In addition, the strain does not produce aflatoxin because of the loss of a regulatory gene, aflR, necessary for the toxin biosynthesis." @default.
• W2071752687 created "2016-06-24" @default.
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• W2071752687 date "2014-01-01" @default.
• W2071752687 modified "2023-09-28" @default.
• W2071752687 title "<i>Aspergillus oryzae</i>S-03 Produces Gingipain Inhibitors as a Virulence Factor for<i>Porphyromonas gingivalis</i>" @default.
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• W2071752687 doi "https://doi.org/10.4167/jbv.2014.44.2.152" @default.
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