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- W2071755517 abstract "1. The relative rate of O2 release from horse r.b.c. suspensions (pH 7·0–7·4) measured with a slow reaction method was investigated in relation to the methæmoglobin formation. 2. A straight-line relationship was found between the relative rate of methæmoglobin formation by sodium nitrite and the increase in the rate of O2 release. 3. A close relationship was also found between the increase in the rate of O2 release and the relative rate of the spontaneous methæmoglobin formation caused by exposure of the r.b.c. suspensions to N2 + CO2 gas mixtures. 4. A methæmoglobin formation uninterrupted by the reduction develops in the suspensions poisoned by sodium azide. The phenomenon is probably caused by a combination between sodium azide and spontaneously formed methæmoglobin [Keilin], this compound being resistant to the intracorpuscular enzymatic reduction of the preformed methæmoglobin. Sodium azide also causes an increase in the rate of O2 release from r.b.c. suspensions. 5. A suggestion is forwarded of a possible part played by the spontaneous methæmoglobin formation as a factor promoting deoxygenation." @default.
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- W2071755517 date "1948-01-10" @default.
- W2071755517 modified "2023-09-25" @default.
- W2071755517 title "INTRACORPUSCULAR METHAEMOGLOBIN FORMATION AND ITS RELATION TO THE RATE OF OXYGEN RELEASE" @default.
- W2071755517 doi "https://doi.org/10.1113/expphysiol.1948.sp000933" @default.
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