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- W2071768017 abstract "The aim of our study was to investigate the contribution of adrenocorticotrope hormone's fragment, ACTH (4–10), on the recovery of postischemic cardiac function. The effects of ACTH (4–10) on caspase-3 activity, cardiomyocyte and endothelial apoptosis, and HO-1 protein expression were studied. Rats were subcutaneously treated with various doses of ACTH (4–10), then 12 h later, anesthetized and hearts were isolated, perfused and subjected to 30 min ischemia followed by 120 min reperfusion. The incidence of reperfusion-induced VF and VT was reduced. Cardiac function including heart rate, coronary flow, aortic flow, and left ventricular developed pressure were recorded. After 120 min reperfusion, 200 μg/kg of ACTH (4–10) significantly improved the recovery of aortic flow, coronary flow and left ventricular developed pressure from their untreated control values of 15.3±0.9 ml/min, 6.5±0.9 ml/min and 10±0.6 kPa to 20.7±1.3 ml/min, 24.8±1.8 ml/min and 13.7±0.7 kPa, respectively. Heart rate did not show a significant change during reperfusion. ACTH (4–10) treatment resulted in a reduction in infarct size, caspase 3 activity, cardiomyocyte and endothelial apoptosis, and an increase in HO-1 expression in the ischemic/reperfused myocardium. Thus, ACTH (4–10) can be a useful tool for the treatment of ischemic/reperfused myocardium." @default.
- W2071768017 created "2016-06-24" @default.
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- W2071768017 date "2007-06-01" @default.
- W2071768017 modified "2023-10-16" @default.
- W2071768017 title "Adrenocorticotrope hormone fragment (4–10) decreases the ischemia/reperfusion induced injury in isolated rat hearts" @default.
- W2071768017 doi "https://doi.org/10.1016/j.yjmcc.2007.03.632" @default.
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