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- W2071769908 abstract "Glial–neuronal interactions have been a focus of research for many years. Recently, the most intriguing findings have been related to astrocytes and radial glial cells. Communication between these classes of glial cells and neurons is thought to be significant during development of the CNS and in plastic phenomena that occur throughout adulthood. This communication involves, among other components, neurotransmitters and their receptors. Glutamate AMPA receptors, for example, are present on both neurons and glial cells and, when expressed in neurons, mediate fast excitatory synaptic transmission. These cation channels comprise four closely related subunits: GluR1–4; the actual component of the channel determines the functional characteristics of the glutamate-gated channel. Unlike the majority of neuronal AMPA receptors, AMPA receptors in Bergmann glia of the cerebellar cortex do not contain the GluR2 subunit, a component that confers Ca2+ permeability to these channels. The biological significance of this difference has remained obscure since it was discovered in 1992." @default.
- W2071769908 created "2016-06-24" @default.
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- W2071769908 date "2001-08-01" @default.
- W2071769908 modified "2023-10-18" @default.
- W2071769908 title "Not much good is left when glia withdraw" @default.
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- W2071769908 doi "https://doi.org/10.1016/s0165-6147(00)01795-8" @default.
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