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• W2071774328 abstract "Vascular relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF) is important for resistance artery function and is underpinned by hyperpolarization of the smooth muscle cells of the blood vessel wall. Debate surrounds the identity of EDHF and its mechanism of action, with the consensus being that there is no universal EDHF. Regional differences in vascular function reflect the complex mechanisms of EDHF. Two primary mechanistic pathways are implicated: (i) myoendothelial gap junctions mediating the spread of endothelial cell hyperpolarization or small signaling molecules (or both) to the smooth muscle; and (ii) diffusible mediators released from the endothelium, including K+ and epoxyeicosatrienoic acids. Here, we discuss the evidence for and against C-type natriuretic peptide (CNP), the latest candidate for a diffusible mediator. Vascular relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF) is important for resistance artery function and is underpinned by hyperpolarization of the smooth muscle cells of the blood vessel wall. Debate surrounds the identity of EDHF and its mechanism of action, with the consensus being that there is no universal EDHF. Regional differences in vascular function reflect the complex mechanisms of EDHF. Two primary mechanistic pathways are implicated: (i) myoendothelial gap junctions mediating the spread of endothelial cell hyperpolarization or small signaling molecules (or both) to the smooth muscle; and (ii) diffusible mediators released from the endothelium, including K+ and epoxyeicosatrienoic acids. Here, we discuss the evidence for and against C-type natriuretic peptide (CNP), the latest candidate for a diffusible mediator." @default.
• W2071774328 created "2016-06-24" @default.
• W2071774328 creator A5012598298 @default.
• W2071774328 creator A5047663687 @default.
• W2071774328 date "2007-02-01" @default.
• W2071774328 modified "2023-09-29" @default.
• W2071774328 title "C-type natriuretic peptide: a new endothelium-derived hyperpolarizing factor?" @default.
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• W2071774328 doi "https://doi.org/10.1016/j.tips.2006.12.007" @default.
• W2071774328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17208309" @default.
• W2071774328 hasPublicationYear "2007" @default.
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