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- W2071781451 abstract "A strict balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is required in order to maintain homeostasis, as well as to efficiently respond to injury and infections. Numbers and fate decisions made by progenitors derived from HSC must also be carefully regulated to sustain large-scale production of blood cells. The complex Wnt family of molecules generally is thought to be important to these processes, delivering critical signals to HSC and progenitors as they reside in specialized niches. Wnt proteins have also been extensively studied in connection with malignancies and are causatively involved in the development of several types of leukemias. However, studies with experimental animal models have produced contradictory findings regarding the importance of Wnt signals for normal hematopoiesis and lymphopoiesis. Here, we will argue that dose dependency of signaling via particular Wnt pathways accounts for much, if not all of this controversy. We conclude that there seems little doubt that Wnt proteins are required to sustain normal hematopoiesis, but are likely to be presented in carefully controlled gradients in a tissue-specific manner." @default.
- W2071781451 created "2016-06-24" @default.
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- W2071781451 creator A5040837473 @default.
- W2071781451 creator A5042546788 @default.
- W2071781451 creator A5075093137 @default.
- W2071781451 date "2011-12-15" @default.
- W2071781451 modified "2023-10-12" @default.
- W2071781451 title "Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development" @default.
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- W2071781451 doi "https://doi.org/10.1038/leu.2011.387" @default.
- W2071781451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3378318" @default.
- W2071781451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22173215" @default.
- W2071781451 hasPublicationYear "2011" @default.
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