FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071783132> ?p ?o ?g. }

• W2071783132 endingPage "49" @default.
• W2071783132 startingPage "43" @default.
• W2071783132 abstract "The FOXO transcription factors play a key role in cell cycle control, apoptosis, DNA repair, oxidative stress resistance, and longevity. In this study, we demonstrated that the acetyltransferase p300/CBP associated factor (PCAF) functions as a negative regulator of FOXO1. We showed that PCAF bound to the forkhead domain of FOXO1 and acetylated FOXO1 at the K242 and K245 residues. However, PCAF repressed FOXO1-induced transcription in an enzymatic activity-independent manner. In contrast, the transcriptional activity of FOXO1 S253A mutant, in which an Akt phosphorylation site is replaced by alanine, was not repressed by PCAF. Akt-induced phosphorylation of FOXO1 is required for its binding to PCAF, whereas the binding between FOXO1 and CBP is independent on FOXO1 S253 phosphorylation. Furthermore, overexpression of PCAF increased nuclear accumulation of FOXO1 even in the presence of serum. These results suggest that PCAF binds to phosphorylated FOXO1 by Akt and acts as a transcriptional corepressor in the nucleus." @default.
• W2071783132 created "2016-06-24" @default.
• W2071783132 creator A5061669692 @default.
• W2071783132 creator A5063610442 @default.
• W2071783132 creator A5069858537 @default.
• W2071783132 date "2009-12-30" @default.
• W2071783132 modified "2023-09-30" @default.
• W2071783132 title "PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner" @default.
• W2071783132 cites W1977351943 @default.
• W2071783132 cites W2001604240 @default.
• W2071783132 cites W2004417257 @default.
• W2071783132 cites W2029503131 @default.
• W2071783132 cites W2047352825 @default.
• W2071783132 cites W2062390485 @default.
• W2071783132 cites W2079102916 @default.
• W2071783132 cites W2079797384 @default.
• W2071783132 cites W2095217266 @default.
• W2071783132 cites W2105746752 @default.
• W2071783132 cites W2107664641 @default.
• W2071783132 cites W2110894784 @default.
• W2071783132 cites W2111447146 @default.
• W2071783132 cites W2138696495 @default.
• W2071783132 cites W2156712995 @default.
• W2071783132 cites W2162865374 @default.
• W2071783132 cites W4231442978 @default.
• W2071783132 doi "https://doi.org/10.3109/10799890903517947" @default.
• W2071783132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20041807" @default.
• W2071783132 hasPublicationYear "2009" @default.
• W2071783132 type Work @default.
• W2071783132 sameAs 2071783132 @default.
• W2071783132 citedByCount "19" @default.
• W2071783132 countsByYear W20717831322012 @default.
• W2071783132 countsByYear W20717831322013 @default.
• W2071783132 countsByYear W20717831322014 @default.
• W2071783132 countsByYear W20717831322016 @default.
• W2071783132 countsByYear W20717831322018 @default.
• W2071783132 countsByYear W20717831322019 @default.
• W2071783132 countsByYear W20717831322020 @default.
• W2071783132 countsByYear W20717831322022 @default.
• W2071783132 countsByYear W20717831322023 @default.
• W2071783132 crossrefType "journal-article" @default.
• W2071783132 hasAuthorship W2071783132A5061669692 @default.
• W2071783132 hasAuthorship W2071783132A5063610442 @default.
• W2071783132 hasAuthorship W2071783132A5069858537 @default.
• W2071783132 hasConcept C104317684 @default.
• W2071783132 hasConcept C107793267 @default.
• W2071783132 hasConcept C119157956 @default.
• W2071783132 hasConcept C11960822 @default.
• W2071783132 hasConcept C1292079 @default.
• W2071783132 hasConcept C140149449 @default.
• W2071783132 hasConcept C146777309 @default.
• W2071783132 hasConcept C158448853 @default.
• W2071783132 hasConcept C1629964 @default.
• W2071783132 hasConcept C185592680 @default.
• W2071783132 hasConcept C2776603820 @default.
• W2071783132 hasConcept C2779649592 @default.
• W2071783132 hasConcept C502942594 @default.
• W2071783132 hasConcept C55493867 @default.
• W2071783132 hasConcept C75217442 @default.
• W2071783132 hasConcept C86339819 @default.
• W2071783132 hasConcept C86803240 @default.
• W2071783132 hasConcept C95444343 @default.
• W2071783132 hasConceptScore W2071783132C104317684 @default.
• W2071783132 hasConceptScore W2071783132C107793267 @default.
• W2071783132 hasConceptScore W2071783132C119157956 @default.
• W2071783132 hasConceptScore W2071783132C11960822 @default.
• W2071783132 hasConceptScore W2071783132C1292079 @default.
• W2071783132 hasConceptScore W2071783132C140149449 @default.
• W2071783132 hasConceptScore W2071783132C146777309 @default.
• W2071783132 hasConceptScore W2071783132C158448853 @default.
• W2071783132 hasConceptScore W2071783132C1629964 @default.
• W2071783132 hasConceptScore W2071783132C185592680 @default.
• W2071783132 hasConceptScore W2071783132C2776603820 @default.
• W2071783132 hasConceptScore W2071783132C2779649592 @default.
• W2071783132 hasConceptScore W2071783132C502942594 @default.
• W2071783132 hasConceptScore W2071783132C55493867 @default.
• W2071783132 hasConceptScore W2071783132C75217442 @default.
• W2071783132 hasConceptScore W2071783132C86339819 @default.
• W2071783132 hasConceptScore W2071783132C86803240 @default.
• W2071783132 hasConceptScore W2071783132C95444343 @default.
• W2071783132 hasIssue "1" @default.
• W2071783132 hasLocation W20717831321 @default.
• W2071783132 hasLocation W20717831322 @default.
• W2071783132 hasOpenAccess W2071783132 @default.
• W2071783132 hasPrimaryLocation W20717831321 @default.
• W2071783132 hasRelatedWork W1972791523 @default.
• W2071783132 hasRelatedWork W2064874105 @default.
• W2071783132 hasRelatedWork W2071783132 @default.
• W2071783132 hasRelatedWork W2091781796 @default.
• W2071783132 hasRelatedWork W2474059146 @default.
• W2071783132 hasRelatedWork W2883079770 @default.
• W2071783132 hasRelatedWork W3130460793 @default.
• W2071783132 hasRelatedWork W3175808378 @default.
• W2071783132 hasRelatedWork W4205114760 @default.
• W2071783132 hasRelatedWork W4309244205 @default.
• W2071783132 hasVolume "30" @default.
• W2071783132 isParatext "false" @default.
• W2071783132 isRetracted "false" @default.

• next